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Cat. No.: HY-113906

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GSK1614343

GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC₅₀ value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models.

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CAS No.: 1092076-04-4
Formule: C₂₂H₂₃F₆N₅O
Masse moléculaire:487.44

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Data Sheet (270 KB)

GSK1614343 Chemical Structure

CAS No.: 1092076-04-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

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GHSR1a

Chemical Information

CAS No. 1092076-04-4
Masse moléculaire 487.44
Formule C₂₂H₂₃F₆N₅O
SMILES

O=C([C@@H](C1=CC=CN=C1)N2C[C@@]3([H])CCCN3CC2)NNC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Perdonà E, et al. Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors. Eur J Pharmacol. 2011;650(1):178-183. [Content Brief]

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GSK1614343

Voir tous les produits spécifiques à Isoform GHSR