HBV-IN-23
HBV-IN-23 (Compound 5k) is an inhibitor of HBV DNA replication with an IC50 of 0.58 μM. HBV-IN-23 inhibits HBV DNA replication in both agent sensitive and resistant HBV strains. HBV-IN-23 shows anti-hepatocellular carcinoma cell (HCC) activities. HBV-IN-23 induces HepG2 cells apoptosis.
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- CAS No.: 2413649-89-3
- Formule: C25H27N3O3S
- Masse moléculaire:449.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
IC50: 0.58 µM (HBV DNA replication)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
5.44 μM
Compound: 5k
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
|
[PMID: 32791397] |
| HepG2 2.2.15 | CC50 |
>10 μM
Compound: 5k
|
Cytotoxicity against human HepG2 2.2.15 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 2.2.15 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32791397] |
| Huh-7 | IC50 |
6.42 μM
Compound: 5k
|
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
|
[PMID: 32791397] |
| SK-HEP1 | IC50 |
6.75 μM
Compound: 5k
|
Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
|
[PMID: 32791397] |
Chemical Information
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CAS No. 2413649-89-3
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Masse moléculaire 449.57
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Formule C25H27N3O3S
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SMILES
CN(CCCOC1=CC=C2N=C(N(C(C2=C1)=O)CC3=CC=CO3)SCC4=CC=CC=C4)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)