Ivospemin hydrochloride
Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers.
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- CAS No.: 259657-09-5
- Formule: C16H42Cl4N4O2
- Masse moléculaire:464.34
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Ivospemin hydrochloride (500 nM to 10 µM, 96 h) reduces cell viability in human ovarian adenocarcinoma cells with IC50 values ranging between 0.95 µM and 3.24 µM regardless of cisplatin sensitivity[2].
IC50 values following Ivospemin treatment in human ovarian adenocarcinoma cell lines[1]
| Cell Line | CaOV-3 | A2780 | OV90 | ACRP |
| Ivospemin 96 h IC50 | 2.56 µM | 0.95 µM | 3.24 µM | 1.41 µM |