259657-09-5
Chemical Structure
Ivospemin hydrochloride
Synonym(s): SBP-101 hydrochloride
- CAS No.: 259657-09-5
- Formula:C16H42Cl4N4O2
- Molecular Weight:464.34
InChIKey: SCDBHUCANIJZED-VNMXSFETSA-N
SMILES: CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC.Cl.Cl.Cl.Cl
Biological Activity: Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers[1][2][3].
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Ivospemin hydrochloride | Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers. | |||||||||||||||||||||
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- [1]. International Nonproprietary Names for Pharmaceutical Substances (INN).
- [2]. Holbert CE, et al. The Polyamine Analogue Ivospemin hydrochloride Increases Chemotherapeutic Efficacy in Murine Ovarian Cancer. Biomedicines. 2024 May 23;12(6):1157. [Content Brief]
- [3]. Liu TA, et al. The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis. Int J Mol Sci. 2024 Jul 26;25(15):8173. [Content Brief]
Keywords
