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Cat. No.: HY-186286

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KRAS-IN-63

KRAS-IN-63 is a KRAS^G12 inhibitor with a pIC₅₀ of 8.11. KRAS-IN-63 can be used in lung cancer-related research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₁H₃₁ClN₆O₂
Masse moléculaire:555.07

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-63 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

KRAS-IN-63 is a KRAS^G12 inhibitor with a pIC₅₀ of 8.11. KRAS-IN-63 can be used in lung cancer-related research^[1].

IC₅₀ & Target^[1]

KRASG12

8.11 (pIC₅₀)

Voir tous les produits spécifiques à Isoform Ras :

In Vitro

KRAS-IN-63 (C9) tightly docks into the Switch-II pocket of KRAS^G12C, and forms a network of hydrogen bonds, electrostatic interactions and hydrophobic interactions with key pocket residues (SER17, THR35, ASP33)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 555.07
Formule C₃₁H₃₁ClN₆O₂
SMILES

O=C1N(C2=C[C@]([C@]3=C4C(NN=C4)=CC=C3C)=C(C=C2C(N5CCN(CC5)C(C)=O)=N1)Cl)C6=C(C=CC=C6)C(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Stephen Adebayo O, et al. QSAR-guided discovery of novel KRAS inhibitors for lung cancer therapy. Frontiers in bioinformatics. 2025;5:1663846. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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KRAS-IN-63

Voir tous les produits spécifiques à Isoform Ras

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

KRAS-IN-63 Related Classifications

HY-186286 Related Classifications