MRTX-1257-d6
MRTX-1257-d6 is the deuterium labeled MRTX-1257 (HY-114436). MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.
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- CAS No.: 2639608-44-7
- Formule: C33H33D6N7O2
- Masse moléculaire:571.75
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2639608-44-7
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Unlabeled Cas 2206736-04-9
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Masse moléculaire 571.75
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Formule C33H33D6N7O2
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SMILES
[2H]C([2H])([2H])N(CCC1)[C@@H]1COC2=NC(N3C[C@@H](N(CC3)C(C=C)=O)CC#N)=C4C(CN(C5=CC=CC6=C5C(C([2H])([2H])[2H])=CC=C6)CC4)=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRTX-1257-d6 Related Classifications
HY-114436S Related Classifications
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