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Cat. No.: HY-133944

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Nitrosulfathiazole

(Synonyms: Nisulfazole; p-Nitrosulfathiazole)

Nitrosulfathiazole (Nisulfazole; p-Nitrosulfathiazole) is a sulfonamide antibacterial agent and also a key chemical intermediate for the hematotoxicity of Chloramphenicol (HY-B0239). Nitrosulfathiazole induces DNA helix instability, strand breakage and aplastic anemia. Nitrosulfathiazole can be used in research related to bacterial infections and aplastic anemia.

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CAS No.: 473-42-7
Formule: C₉H₇N₃O₄S₂
Masse moléculaire:285.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

Nitrosulfathiazole Chemical Structure

CAS No.: 473-42-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

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In Vitro

Nitrosulfathiazole mediates chloramphenicol-induced hematotoxicity by inhibiting DNA synthesis, causing helix destabilization, and inducing strand breakage in bone marrow stem cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 473-42-7
Appearance Solid
Masse moléculaire 285.30
Formule C₉H₇N₃O₄S₂
SMILES

O=S(C1=CC=C([N+]([O-])=O)C=C1)(NC2=NC=CS2)=O
Synonyms

Nisulfazole; p-Nitrosulfathiazole
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Shukla, P., & Singh, R. K. (2013). Effect of oral administration of chloramphenicol on hematological profile of male charles foster rats. Global journal of medical research pharma, drug discovery, toxicology and medicine, 13.

[2]. Holt D, et al. Chloramphenicol toxicity. Adverse Drug React Toxicol Rev. 1993 Summer;12(2):83-95. PMID: 8357947.
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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Nitrosulfathiazole

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Nitrosulfathiazole Related Classifications

HY-133944 Related Classifications