PPTN hydrochloride
Based on 4 publication(s) in Google Scholar
PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity.
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- Pureté: 99.89%
- CAS No.: 1992047-65-0
- Formule: C29H25ClF3NO2
- Masse moléculaire:511.96
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PPTN hydrochloride
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Customer Validation & Images
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WB
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IF
Voir tous les produits spécifiques à Isoform P2Y Receptor
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Activité biologique
KB: 434 pM (P2Y14 receptor)[1]
PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors[1].
PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM[1].
PPTN (10 μM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1992047-65-0
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Appearance Solid
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Masse moléculaire 511.96
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Formule C29H25ClF3NO2
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Color White to off-white
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SMILES
FC(F)(C1=CC=C(C2=CC=C3C(C4=CC=C(C=C4)C5CCNCC5)=CC(C(O)=O)=CC3=C2)C=C1)F.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Rep
Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG. [Abstract]2025 Nov 18;44(12):116577. PMID: 41259203 -
Int Immunopharmacol
HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis. [Abstract]2023 Jan:114:109507. PMID: 36462336
PPTN hydrochloride purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Jan:114:109507. [Abstract]
HQL6 or PPTN significantly decreases the expressions of NLRP3, ASC and caspase-1 p20 in synovial tissue of rats.
PPTN hydrochloride purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Jan:114:109507. [Abstract]
HQL6 or PPTN significantly decreases the colocalization of NLRP3 and ASC in synovial tissues of rats. NLRP3 protein, ASC protein and nucleus are marked with Alexa Fluor 488 (Green), Alexa Fluor 647 (Red) and DAPI (Blue), respectively.
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Neuropharmacology
2025 Oct 14:110723. PMID: 41101520 -
Clin Immunol
Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus. [Abstract]2024 Aug:265:110300. PMID: 38950722
Solvant et solubilité
DMSO : 66.67 mg/mL (130.23 mM; adjust pH to 11 with 1 M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9. [Content Brief]
[2]. Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9533 mL | 9.7664 mL | 19.5328 mL | 48.8319 mL |
| 5 mM | 0.3907 mL | 1.9533 mL | 3.9066 mL | 9.7664 mL | |
| 10 mM | 0.1953 mL | 0.9766 mL | 1.9533 mL | 4.8832 mL | |
| 15 mM | 0.1302 mL | 0.6511 mL | 1.3022 mL | 3.2555 mL | |
| 20 mM | 0.0977 mL | 0.4883 mL | 0.9766 mL | 2.4416 mL | |
| 25 mM | 0.0781 mL | 0.3907 mL | 0.7813 mL | 1.9533 mL | |
| 30 mM | 0.0651 mL | 0.3255 mL | 0.6511 mL | 1.6277 mL | |
| 40 mM | 0.0488 mL | 0.2442 mL | 0.4883 mL | 1.2208 mL | |
| 50 mM | 0.0391 mL | 0.1953 mL | 0.3907 mL | 0.9766 mL | |
| 60 mM | 0.0326 mL | 0.1628 mL | 0.3255 mL | 0.8139 mL | |
| 80 mM | 0.0244 mL | 0.1221 mL | 0.2442 mL | 0.6104 mL | |
| 100 mM | 0.0195 mL | 0.0977 mL | 0.1953 mL | 0.4883 mL |
PPTN hydrochloride Related Classifications
HY-110322 Related Classifications
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