(R)-C12-200
(R)-C12-200 is the (R)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (R)-C12-200 enables functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mice, with minimal off-target delivery to liver or spleen. (R)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery.
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- CAS No.: 1226777-45-2
- Formule: C70H145N5O5
- Masse moléculaire:1136.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
(R)-C12-200-containing LNPIT (1 μg LNPIT-PNP mRNA per well; 24 h pre-prodrug incubation, 100 μM MeP-dR, 4 days incubation) enables PNP mRNA delivery and subsequent prodrug activation, leading to potent cell killing in FaDu, MOC1, PDX1, PDX2, PDX3, and PDX4 HNSCC cells in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1226777-45-2
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Masse moléculaire 1136.93
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Formule C70H145N5O5
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SMILES
CCCCCCCCCC[C@@H](O)CN(C[C@H](O)CCCCCCCCCC)CCN(C[C@H](O)CCCCCCCCCC)CCN1CCN(CC1)CCN(C[C@H](O)CCCCCCCCCC)C[C@H](O)CCCCCCCCCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-C12-200 Related Classifications
HY-W1130459 Related Classifications
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