1226777-45-2
Chemical Structure
(R)-C12-200
- CAS No.: 1226777-45-2
- Formula:C70H145N5O5
- Molecular Weight:1136.93
IUPAC Name: (2R,2'R)-1,1'-((2-(4-(2-((2-(bis((R)-2-hydroxydodecyl)amino)ethyl)((R)-2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
InChIKey: RVHYPUORVDKRTM-ZSTXVYJSSA-N
SMILES: CCCCCCCCCC[C@@H](O)CN(C[C@H](O)CCCCCCCCCC)CCN(C[C@H](O)CCCCCCCCCC)CCN1CCN(CC1)CCN(C[C@H](O)CCCCCCCCCC)C[C@H](O)CCCCCCCCCC
Biological Activity: (R)-C12-200 is the (R)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (R)-C12-200 enables functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mice, with minimal off-target delivery to liver or spleen. (R)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery[1].
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(R)-C12-200 | (R)-C12-200 is the (R)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (R)-C12-200 enables functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mice, with minimal off-target delivery to liver or spleen. (R)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery. | |||||||||||||||||||||
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