113 Results for "

RGD

" in MedChemExpress (MCE) Product Catalog:
Products (113)

113 Results for "RGD" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-P0278
CAS No.: 99896-85-2
Target:  

Integrin

Domaines de recherche:  

Cancer

RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
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9
9 Publications Verification
Cat. No.: HY-P1740
CAS No.: 114681-65-1
Target:  

Integrin Apoptosis Caspase

Domaines de recherche:  

Inflammation/Immunology

RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .
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9
9 Publications Verification
Cat. No.: HY-P0278A
CAS No.: 2378808-45-6
Target:  

Integrin

Domaines de recherche:  

Cancer

RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.
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9
9 Publications Verification
Cat. No.: HY-P1740A
Target:  

Integrin Apoptosis

Domaines de recherche:  

Inflammation/Immunology Cancer

RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation .
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5
5 Cited Publications
Cat. No.: HY-P0290
CAS No.: 91037-75-1
Target:  

Integrin

Domaines de recherche:  

Cancer

GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
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4
4 Cited Publications
Cat. No.: HY-P1408
CAS No.: 404882-00-4
Target:  

Integrin VEGFR

Domaines de recherche:  

Cancer

Obtustatin is a non-RGD disintegrin consisting of 41 residues. Obtustatin inhibits the adhesion of α1β1 integrin to type IV Collagen (HY-NP003), blocks α1β1 integrin signaling in endothelial cells, and suppresses FGF2-induced angiogenesis. Obtustatin inhibits tumor progression in mouse models and upregulates VEGF expression in sarcoma-bearing mice. Obtustatin can be used in research related to Lewis lung carcinoma and S-180 sarcoma .
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4
4 Cited Publications
Cat. No.: HY-P1408A
Target:  

Integrin

Domaines de recherche:  

Cancer

Obtustatin triacetate is a 41-residue non-RGD disintegrin. Obtustatin triacetate can be isolated from the venom of Vipera lebetina obtusa. Obtustatin triacetate is a potent and selective inhibitor of integrin α1β1 adhesion to type IV collagen. Obtustatin triacetate inhibits angiogenesis and may be used in cancer research .
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2
2 Cited Publications
Cat. No.: HY-166648
DSPE-PEG2000-Maleimide sodium (purity>98%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>98%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>98%) is applicable to research on drug delivery .
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2
2 Cited Publications
Cat. No.: HY-W053583
CAS No.: 60239-18-1
Synonyms: DOTA
Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) .
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2
2 Cited Publications
Cat. No.: HY-P2300
CAS No.: 862772-11-0
Synonyms: Cyclo(RGDfC)
Target:  

Integrin

Domaines de recherche:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
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2
2 Cited Publications
Cat. No.: HY-134130
CAS No.: 2023788-32-9
Pureté:  99.80%
Target:  

Integrin

Domaines de recherche:  

Inflammation/Immunology

Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM .
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2
2 Cited Publications
Cat. No.: HY-166648A
Target:  

Liposome

Domaines de recherche:  

Others

DSPE-PEG-Maleimide ammonium (MW 2000) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG-Maleimide ammonium (MW 2000) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG (2000)-RGD. DSPE-PEG-Maleimide ammonium (MW 2000) is applicable to research on drug delivery .
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2
2 Cited Publications
Cat. No.: HY-P2300A
Synonyms: Cyclo(RGDfC) TFA
Target:  

Integrin

Domaines de recherche:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) TFA, a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA can be used in the research of tumors .
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2
2 Cited Publications
Cat. No.: HY-P81210
Synonyms: LATS1 +LATS2 (phospho T1079 + T1041); Serine/threonine protein kinase LATS2; KPM; Large tumor supressor, homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS, large tumor suppressor, homolog 2 (Drosophila); LATS1 +LATS2 (phospho T1079 + T1041); p-LATS1 +LATS2(Thr1079 +Thr1041); RGD1564085; Serine/threonine protein kinase LATS1; WARTS; WARTS protein kinase; wts; 4932411G09Rik; AV277261; AW208599; AW228608; FLJ13161; LATS1_HUMAN.

Host:  

Rabbit

Application:  

WB, ELISA, IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Mouse, Rabbit

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1
1 Cited Publications
Cat. No.: HY-P99291
CAS No.: 892553-42-3
Synonyms: LM609; MEDI-522

Target:  

Integrin Apoptosis Akt

Domaines de recherche:  

Cancer

Etaracizumab (LM 609) is an αvβ3 integrin IgG mAb. Etaracizumab is developed to target αvβ3+ cancer cells via NK cell-mediated cytotoxicity. Etaracizumab sterically hinders access of large ligands to the RGD-binding pocket, without obstructing it. Etaracizumab decreases p-Akt in vitro. Etaracizumab can decrease cancer proliferation and invasion. Etaracizumab induces tumor cell apoptosis, and inhibition ofαvβ3-mediated cell adhesion, endothelial cell migration and osteoclast-mediated bone resorption. Etaracizumab can be studied in anti-tumor research against cancers such as ovarian cancer, metastatic melanoma as well as advanced solid tumors. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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1
1 Cited Publications
Cat. No.: HY-P74525A
Pureté:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBI; RGD-Containing Collagen-Associated Protein; Prev. CSD1; Beta Ig-H3; Prev. CSD2; RGD-CAP; Prev. CSD3; Transforming Growth Factor, Beta-Induced, 68kDa; Prev. LCD1; Transforming Growth Factor Beta-Induced 68kDa; BIGH3; Transforming Growth Factor Beta
Species:  
Source:  
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Cat. No.: HY-19307
CAS No.: 205678-31-5
SB-273005 is an orally active non-peptide αvβ3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for αvβ3 and αvβ5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. .
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Cat. No.: HY-P3732
CAS No.: 332179-76-7
Target:  

Integrin

Domaines de recherche:  

Cancer

RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models .
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Cat. No.: HY-P0322
CAS No.: 111119-28-9
Synonyms: EMD 56574
Target:  

Integrin

Domaines de recherche:  

Cardiovascular Disease Metabolic Disease

GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .
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Cat. No.: HY-P3448
CAS No.: 2580154-02-3
Synonyms: CEND-1; iRGD; LSTA1
Domaines de recherche:  

Cancer

Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors .
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