Selurampanel
Based on 1 Customer Validation
Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.28%
- CAS No.: 912574-69-7
- Formule: C16H19N5O4S
- Masse moléculaire:377.42
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 912574-69-7
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Appearance Solid
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Masse moléculaire 377.42
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Formule C16H19N5O4S
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Color White to off-white
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SMILES
CC(C1=C(C2=CC=NN2C)C=C3C(NC(N(NS(C)(=O)=O)C3=O)=O)=C1)C
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Synonyms
BGG 492
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 27.5 mg/mL (72.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. David Orain, et al. Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist. ChemMedChem. 2017 Feb 3;12(3):197-201. [Content Brief]
[2]. Edward Faught, et al. BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy. Expert Opin Investig Drugs. 2014 Jan;23(1):107-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6496 mL | 13.2478 mL | 26.4957 mL | 66.2392 mL |
| 5 mM | 0.5299 mL | 2.6496 mL | 5.2991 mL | 13.2478 mL | |
| 10 mM | 0.2650 mL | 1.3248 mL | 2.6496 mL | 6.6239 mL | |
| 15 mM | 0.1766 mL | 0.8832 mL | 1.7664 mL | 4.4159 mL | |
| 20 mM | 0.1325 mL | 0.6624 mL | 1.3248 mL | 3.3120 mL | |
| 25 mM | 0.1060 mL | 0.5299 mL | 1.0598 mL | 2.6496 mL | |
| 30 mM | 0.0883 mL | 0.4416 mL | 0.8832 mL | 2.2080 mL | |
| 40 mM | 0.0662 mL | 0.3312 mL | 0.6624 mL | 1.6560 mL | |
| 50 mM | 0.0530 mL | 0.2650 mL | 0.5299 mL | 1.3248 mL | |
| 60 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1040 mL |
Selurampanel Related Classifications
HY-105860 Related Classifications
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