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Cat. No.: HY-165438

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Sergliflozin-A

Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.

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CAS No.: 360775-96-8
Formule: C₂₀H₂₄O₇
Masse moléculaire:376.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Sergliflozin-A Chemical Structure

CAS No.: 360775-96-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Description
- IC₅₀ & Target
- Cellular Effect
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Description

IC₅₀ & Target

SGLT1

SGLT2

Voir tous les produits spécifiques à Isoform SGLT :

SGLT1
SGLT2

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	9.2 nM Compound: 4a	Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation	[PMID: 18260618]
CHO	EC₅₀	>8000 nM Compound: 4a	Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation	[PMID: 18260618]
CHO	IC₅₀	6.25 nM Compound: 6	Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting	[PMID: 20181486]
CHO	IC₅₀	2300 nM Compound: 3-active	Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins	[PMID: 21873071]
CHO	IC₅₀	4.8 nM Compound: 3-active	Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins	[PMID: 21873071]
CHO-K1	IC₅₀	2300 nM Compound: 2-A	Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay	[PMID: 22652255]
CHO-K1	IC₅₀	4.8 nM Compound: 2-A	Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay	[PMID: 22652255]

Chemical Information

CAS No. 360775-96-8
Masse moléculaire 376.40
Formule C₂₀H₂₄O₇
SMILES

COC(C=C1)=CC=C1CC(C=CC=C2)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and …

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Sergliflozin-A

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform SGLT

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Sergliflozin-A Related Classifications

HY-165438 Related Classifications