Tetrachlorohydroquinone
Based on 1 Customer Validation
Tetrachlorohydroquinone (TCHQ) is a metabolite of Pentachlorophenol. Tetrachlorohydroquinone induces reactive oxidant stress (ROS), inhibits apoptosis and induces necrosis in primary mouse splenocytes. Tetrachlorohydroquinone increases DNA lesions and induces oxidative stress in rodents.
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- Pureté: 98.45%
- CAS No.: 87-87-6
- Formule: C6H2Cl4O2
- Masse moléculaire:247.89
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
In the presence of oxygen, Tetrachlorohydroquinone can lead to production of superoxide radicals through a cycle of autoxidation and reduction between Tetrachlorohydroquinone and its corresponding semiquinone radical under certain physiological conditions[1].
Tetrachlorohydroquinone (12.5-50 µM; 0.25-6 hr) induces obvious cytotoxicity in the splenocytes in a time- and dose-dependent manner. Tetrachlorohydroquinone decreases the spontaneous apoptosis[1].
Tetrachlorohydroquinone (12.5-50 µM; 0.25-2 hr) inhibits caspase-3 activity and PARP cleavage[1].
Tetrachlorohydroquinone (12.5-50 µM; 0.25-2 hr) leads to necrotic cell death of the splenocytes through induction of massive and sudden ROS and prolonged ROS-triggered ERK activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Splenocytes isolated from male ICR mice
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Concentration:12.5 µM, 25 µM, 50 µM
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Incubation Time:0.25 h, 0.5 h, 1 h, 2 h, 4 h, 6 h
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Result:Induced obvious cytotoxicity in the splenocytes in a time- and dose-dependent manner.
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Cell Line:Splenocytes isolated from male ICR mice
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Concentration:12.5 µM, 25 µM, 50 µM
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Incubation Time:0.25 h, 0.5 h, 1 h, 2 h, 6 h
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Result:Increased the percentage of the sub-G0/G1 cells and DNA laddering.
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Cell Line:Splenocytes isolated from male ICR mice
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Concentration:12.5 µM, 25 µM, 50 µM
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Incubation Time:0.25 h, 0.5 h, 1 h, 2 h, 6 h
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Result:Dramatically decreased the spontaneous apoptosis of the splenocytes in a dose- and time-dependent manner.
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Cell Line:Splenocytes isolated from male ICR mice
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Concentration:12.5 µM, 25 µM, 50 µM
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Incubation Time:0.25 h, 2 h
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Result:Inhibited caspase-3 activity and PARP cleavage.
Chemical Information
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CAS No. 87-87-6
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Appearance Solid
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Masse moléculaire 247.89
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Formule C6H2Cl4O2
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Color White to light yellow
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SMILES
C1(=C(C(=C(C(=C1Cl)O)Cl)Cl)O)Cl
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Synonyms
TCHQ; Tetrachloroquinol
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 200 mg/mL (806.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.0340 mL | 20.1702 mL | 40.3405 mL | 100.8512 mL |
| 5 mM | 0.8068 mL | 4.0340 mL | 8.0681 mL | 20.1702 mL | |
| 10 mM | 0.4034 mL | 2.0170 mL | 4.0340 mL | 10.0851 mL | |
| 15 mM | 0.2689 mL | 1.3447 mL | 2.6894 mL | 6.7234 mL | |
| 20 mM | 0.2017 mL | 1.0085 mL | 2.0170 mL | 5.0426 mL | |
| 25 mM | 0.1614 mL | 0.8068 mL | 1.6136 mL | 4.0340 mL | |
| 30 mM | 0.1345 mL | 0.6723 mL | 1.3447 mL | 3.3617 mL | |
| 40 mM | 0.1009 mL | 0.5043 mL | 1.0085 mL | 2.5213 mL | |
| 50 mM | 0.0807 mL | 0.4034 mL | 0.8068 mL | 2.0170 mL | |
| 60 mM | 0.0672 mL | 0.3362 mL | 0.6723 mL | 1.6809 mL | |
| 80 mM | 0.0504 mL | 0.2521 mL | 0.5043 mL | 1.2606 mL | |
| 100 mM | 0.0403 mL | 0.2017 mL | 0.4034 mL | 1.0085 mL |
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