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Cat. No.: HY-146115

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TRK-IN-19

TRK-IN-19 (Compound I-10 ) is a potent inhibitor of TRK (TRKA IC₅₀ = 1.1 nM, TRKA^G595R IC₅₀ = 5.3 nM). TRK-IN-19 has the potential for the research of cancer diseases.

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Formule: C₂₂H₂₆FN₅O₂
Masse moléculaire:411.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TRK-IN-19 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

TRK-IN-19 (Compound I-10 ) is a potent inhibitor of TRK (TRKA IC₅₀ = 1.1 nM, TRKA^G595R IC₅₀ = 5.3 nM). TRK-IN-19 has the potential for the research of cancer diseases^[1].

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Chemical Information

Masse moléculaire 411.47
Formule C₂₂H₂₆FN₅O₂
SMILES

COC1CCC(CC1)NC(C2=C3N=C(C=CN3N=C2)N(CC4=CC(F)=CC=C4)C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sun M, et al. Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115811. doi: 10.1016/j.bmc.2020.115811. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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TRK-IN-19

Voir tous les produits spécifiques à Isoform Trk Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TRK-IN-19 Related Classifications

HY-146115 Related Classifications