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Cat. No.: HY-147779

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VEGFR-2-IN-20

VEGFR-2-IN-20 (Compound 7) is a potent inhibitor of VEGFR. VEGFR-2-IN-20 has the potential for the research of cancer diseases.

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CAS No.: 2404581-25-3
Formule: C₂₀H₂₀N₄O₃S
Masse moléculaire:396.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

VEGFR-2-IN-20 Chemical Structure

CAS No.: 2404581-25-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

VEGFR-2-IN-20 (Compound 7) is a potent inhibitor of VEGFR. VEGFR-2-IN-20 has the potential for the research of cancer diseases^[1].

Voir tous les produits spécifiques à Isoform VEGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4.58 μM Compound: 39	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay	[PMID: 38728867]
HCT-116	IC₅₀	4.83 μM Compound: 83	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay	[PMID: 37453330]
HepG2	IC₅₀	3.97 μM Compound: 39	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay	[PMID: 38728867]
HepG2	IC₅₀	3.97 μM Compound: 83	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay	[PMID: 37453330]
MCF7	IC₅₀	4.58 μM Compound: 83	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay	[PMID: 37453330]
MCF7	IC₅₀	4.83 μM Compound: 39	Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay	[PMID: 38728867]

Chemical Information

CAS No. 2404581-25-3
Masse moléculaire 396.46
Formule C₂₀H₂₀N₄O₃S
SMILES

CCN1C(C2=CC=CC=C2N=C1SCC(NC3=CC=C(C=C3)/C(C)=N/O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Eissa IH, et al. Discovery of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation. Bioorg Chem. 2020;105:104380. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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VEGFR-2-IN-20

Voir tous les produits spécifiques à Isoform VEGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VEGFR-2-IN-20 Related Classifications

HY-147779 Related Classifications