57423-72-0
Chemical Structure
Withaphysalin A
- CAS No.: 57423-72-0
- Formula:C28H34O6
- Molecular Weight:466.57
IUPAC Name: (1S,3R,3aS,5aS,5bS,7R,7aS,11aR,11bS,13aR)-3-((R)-4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-7,7a-dihydroxy-1-methoxy-3,11a-dimethyl-3,3a,4,5,5a,5b,6,7,7a,8,11a,11b,12,13-tetradecahydro-1H,11H-naphtho[2',1':4,5]indeno[1,7a-c]furan-11-one
InChIKey: XXDCTQHRVNTDTI-WBJFYKDLSA-N
SMILES: CC(CC([C@@]1(OC([C@]23CCC4C([C@@]2(CCC31)O)CC=C5CC=CC([C@]45C)=O)=O)C)O6)=C(C)C6=O
Biological Activity: Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS (HY-D1056)-induced nuclear translocation of NF-κB p65, as well as phosphorylation of STAT3, ERK, JNK and p38 MAPK. Withaphysalin A upregulates the expression of HO-1. Withaphysalin A inhibits LPS-induced production of NO, PGE2, IL-1β, IL-6 and TNF-α. Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2. Withaphysalin A interacts with B-cell activating factor protein (BAFF) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Withaphysalin A | 98% | Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS (HY-D1056)-induced nuclear translocation of NF-κB p65, as well as phosphorylation of STAT3, ERK, JNK and p38 MAPK. Withaphysalin A upregulates the expression of HO-1. Withaphysalin A inhibits LPS-induced production of NO, PGE2, IL-1β, IL-6 and TNF-α. Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2. Withaphysalin A interacts with B-cell activating factor protein (BAFF) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia. | ||||||||||||||||||||
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References
- [1]. Li RJ, et al. The Anti-inflammatory Activities of Two Major Withanolides from Physalis minima Via Acting on NF-κB, STAT3, and HO-1 in LPS-Stimulated RAW264.7 Cells. Inflammation. 2017;40(2):401-413. [Content Brief]
- [2]. Kardani AK, et al. Inhibition of B-cell activating factor activity using active compounds from Physalis angulata in the mechanism of nephrotic syndrome improvement: A computational approach. Narra J. 2024 Dec;4(3):e859. [Content Brief]
- [3]. Tasneem A, et al. Exploring phytochemical inhibitors of fatty acid elongase ELOVL6 for targeted treatment of chronic myeloid leukemia: A comprehensive network-based drug discovery approach. Comput Biol Med. 2026;201:111342. [Content Brief]
