[Met5]-Enkephalin, amide
[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.
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- CAS. Nr.: 60117-17-1
- Formel: C27H36N6O6S
- Molecular Weight:572.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[Met5]-Enkephalin, amide Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p1467.gif "Click to View [Met5]-Enkephalin, amide Chemical Structure")
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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δ Opioid Receptor/DOR |
[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 60117-17-1
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Molecular Weight 572.68
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Formel C27H36N6O6S
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Synonyms
5-Methionine-enkephalin amide
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Sequence
Tyr-Gly-Gly-Phe-Met-NH2
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Sequence Shortening
YGGFM-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48. [Content Brief]
[2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
[Met5]-Enkephalin, amide Related Classifications
HY-P1467 Related Classifications
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