1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. [Met5]-Enkephalin, amide TFA

[Met5]-Enkephalin, amide TFA (Synonyms: 5-Methionine-enkephalin amide (TFA))

Cat. No.: HY-P1467A Purity: 99.71%
Handling Instructions

[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Met5]-Enkephalin, amide TFA Chemical Structure

[Met5]-Enkephalin, amide TFA Chemical Structure

Size Price Stock Quantity
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
25 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of [Met5]-Enkephalin, amide TFA:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review


[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

IC50 & Target

δ and ζ opioid receptor[1]

In Vitro

[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight






Sequence Shortening



Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (145.62 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4562 mL 7.2812 mL 14.5624 mL
5 mM 0.2912 mL 1.4562 mL 2.9125 mL
10 mM 0.1456 mL 0.7281 mL 1.4562 mL
*Please refer to the solubility information to select the appropriate solvent.
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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


[Met5]-Enkephalin, amide5-Methionine-enkephalin amideOpioid ReceptorInhibitorinhibitorinhibit

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