1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. [Met5]-Enkephalin, amide

[Met5]-Enkephalin, amide (Synonyms: 5-Methionine-enkephalin amide)

Cat. No.: HY-P1467
Handling Instructions

[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Met5]-Enkephalin, amide Chemical Structure

[Met5]-Enkephalin, amide Chemical Structure

CAS No. : 60117-17-1

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Description

[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

IC50 & Target

δ and ζ opioid receptor[1]

In Vitro

[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

572.68

Formula

C₂₇H₃₆N₆O₆S

CAS No.

60117-17-1

Sequence

Tyr-Gly-Gly-Phe-Met-NH2

Sequence Shortening

YGGFM-NH2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
[Met5]-Enkephalin, amide
Cat. No.:
HY-P1467
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[Met5]-Enkephalin, amide

Cat. No.: HY-P1467