6BrCaQ-C10-TPP
6BrCaQ-C10-TPP is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity in various human cancer cells (IC50=0.008-0.30 μM). 6BrCaQ-C10-TPP can also induces mitochondrial membrane disturbance.
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- CAS. Nr.: 3036044-73-9
- Formel: C45H47Br2N2O3P
- Molecular Weight:854.65
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
<0.1 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human HT-29 cells assessed as reduction in viable cells incubated for 72 hrs by trypan blue staining based optical microscopic analysis relative to control
Cytotoxicity against human HT-29 cells assessed as reduction in viable cells incubated for 72 hrs by trypan blue staining based optical microscopic analysis relative to control
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[PMID: 34952432] |
| HT-29 | IC50 |
<1 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 34952432] |
| MDA-MB-231 | GI50 |
0.008 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
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[PMID: 34952432] |
| MDA-MB-231 | IC50 |
0.008 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
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[PMID: 34952432] |
Chemical Information
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CAS. Nr. 3036044-73-9
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Molecular Weight 854.65
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Formel C45H47Br2N2O3P
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SMILES
CN1C(C(NC(C2=CC=C(C=C2)OCCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=CC6=CC(Br)=CC=C61)=O.[Br-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
6BrCaQ-C10-TPP Related Classifications
HY-144831 Related Classifications
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