Toltrazuril sulfone
Based on 1 publication(s) in Google Scholar
Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry.
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- Reinheit: 98.59%
- CAS. Nr.: 69004-04-2
- Formel: C18H14F3N3O6S
- Molecular Weight:457.38
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Toltrazuril sulfone
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Biologische Aktivität
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Coccidia |
Toltrazuril sulfone inhibits the development of merozoites of S. neurona[1].
Toltrazuril sulfone inhibits the development of N. caninum after approximately 48 h post-exposure[1].
Toltrazuril sulfone exhibits inhibitory possibly by targeting different enzyme/enzyme systems in different apicomplexans[1].
Toltrazuril sulfone (5 mg/ml; 20 hours) inhibits T. gondii replication after the second division by endodyogeny[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice[2]
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Dosage:10 mg/kg, 20 mg/kg
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Administration:Oral administration, daily, for 10 days
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Result:Prevented and protected mice from toxoplasmosis.
Chemical Information
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CAS. Nr. 69004-04-2
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Appearance Solid
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Molecular Weight 457.38
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Formel C18H14F3N3O6S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C=C1)OC2=C(C=C(C=C2)N3C(N(C(NC3=O)=O)C)=O)C)(C(F)(F)F)=O
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Synonyms
Ponazuril
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Pestic Biochem Physiol
2025 Sep:213:106524. PMID: 40744572
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (109.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.47 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Sheila M Mitchell, et al. The effects of ponazuril on development of apicomplexans in vitro. J Eukaryot Microbiol. May-Jun 2005;52(3):231-5. [Content Brief]
[2]. Sheila M Mitchell, et al. Efficacy of ponazuril in vitro and in preventing and treating Toxoplasma gondii infections in mice. J Parasitol. 2004 Jun;90(3):639-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1864 mL | 10.9318 mL | 21.8637 mL | 54.6591 mL |
| 5 mM | 0.4373 mL | 2.1864 mL | 4.3727 mL | 10.9318 mL | |
| 10 mM | 0.2186 mL | 1.0932 mL | 2.1864 mL | 5.4659 mL | |
| 15 mM | 0.1458 mL | 0.7288 mL | 1.4576 mL | 3.6439 mL | |
| 20 mM | 0.1093 mL | 0.5466 mL | 1.0932 mL | 2.7330 mL | |
| 25 mM | 0.0875 mL | 0.4373 mL | 0.8745 mL | 2.1864 mL | |
| 30 mM | 0.0729 mL | 0.3644 mL | 0.7288 mL | 1.8220 mL | |
| 40 mM | 0.0547 mL | 0.2733 mL | 0.5466 mL | 1.3665 mL | |
| 50 mM | 0.0437 mL | 0.2186 mL | 0.4373 mL | 1.0932 mL | |
| 60 mM | 0.0364 mL | 0.1822 mL | 0.3644 mL | 0.9110 mL | |
| 80 mM | 0.0273 mL | 0.1366 mL | 0.2733 mL | 0.6832 mL | |
| 100 mM | 0.0219 mL | 0.1093 mL | 0.2186 mL | 0.5466 mL |
Toltrazuril sulfone Related Classifications
HY-17008 Related Classifications
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