Uridine 5'-monophosphate
Based on 2 publication(s) in Google Scholar
Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
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- Reinheit: 99.98%
- CAS. Nr.: 58-97-9
- Formel: C9H13N2O9P
- Molecular Weight:324.18
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Apoptosis Compound Library
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Publications Citing Use of MedChemExpress (MCE) Uridine 5'-monophosphate
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Biologische Aktivität
Uridine 5'-monophosphate (10 mM; 6 h) promotes late apoptosis in pig intestinal epithelial cells IPEC-J2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IPEC-J2
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Concentration:10 mM
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Incubation Time:6 h
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Result:Increased the late apoptosis rate.
Uridine 5'-monophosphate (0.02-1 mmol/kg; i.g.; single dose) can enhance the synthesis of CDP-choline in the brains of gerbils[2].
Uridine 5'-monophosphate (30 mg/kg; i.v.; single dose) has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Piglets[1]
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Dosage:476 mg, daily, 10 days
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Administration:Oral
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Result:Improved daily weight gain in piglets, reduced diarrhea rates, lowered the expression of jejunal mucosal CAD and RRM2, and increased the apoptosis rate of intestinal epithelial cells.
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Animal Model:Male gerbils (60-80g)[2]
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Dosage:0.02, 0.05, 0.1, 1 mmol/kg, single dose
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Administration:i.g.
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Result:Increased choline levels after 15 minutes, and after thirty minutes, plasma uridine and brain tissue uridine increased, with plasma and brain cytidine also rising significantly.
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Animal Model:Male wistar rats (250-300 g)[3]
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Dosage:30 mg/kg, single dose
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Administration:Intravenous injection (i.v.)
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Result:Reduced the index of myocardial ischemia changes and T-wave amplitude, decreased the frequency of ventricular premature beats, and shortened the duration of ventricular tachycardia and fibrillation.
Chemical Information
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CAS. Nr. 58-97-9
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Appearance Solid
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Molecular Weight 324.18
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Formel C9H13N2O9P
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O)(O)=O
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Synonyms
5'-Uridylic acid
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
J Pharm Biomed Anal
A novel UHPLC-MS/MS approach for simultaneous quantification of pyrimidine metabolites in human biofluids. [Abstract]2025 Jun 17:265:117026. PMID: 40544701
Lösungsmittel & Löslichkeit
H2O : 150 mg/mL (462.71 mM; Need ultrasonic)
DMSO : 100 mg/mL (308.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (15.42 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (15.42 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (308.47 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Li G, et al. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food Funct. 2019 Jul 17;10(7):4081-4089. [Content Brief]
[2]. Mehmet Cansev, et al. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058(1-2):101-8. [Content Brief]
[3]. Irina B Krylova, et al. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Exp Gerontol. 2006 Jul;41(7):697-703. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 3.0847 mL | 15.4235 mL | 30.8471 mL | 77.1177 mL |
| 5 mM | 0.6169 mL | 3.0847 mL | 6.1694 mL | 15.4235 mL | |
| 10 mM | 0.3085 mL | 1.5424 mL | 3.0847 mL | 7.7118 mL | |
| 15 mM | 0.2056 mL | 1.0282 mL | 2.0565 mL | 5.1412 mL | |
| 20 mM | 0.1542 mL | 0.7712 mL | 1.5424 mL | 3.8559 mL | |
| 25 mM | 0.1234 mL | 0.6169 mL | 1.2339 mL | 3.0847 mL | |
| 30 mM | 0.1028 mL | 0.5141 mL | 1.0282 mL | 2.5706 mL | |
| 40 mM | 0.0771 mL | 0.3856 mL | 0.7712 mL | 1.9279 mL | |
| 50 mM | 0.0617 mL | 0.3085 mL | 0.6169 mL | 1.5424 mL | |
| 60 mM | 0.0514 mL | 0.2571 mL | 0.5141 mL | 1.2853 mL | |
| 80 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9640 mL | |
| 100 mM | 0.0308 mL | 0.1542 mL | 0.3085 mL | 0.7712 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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