AChE/BChE-IN-10
Based on 1 Customer Validation
AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.67%
- CAS. Nr.: 2924824-48-4
- Formel: C26H30N2O2
- Molecular Weight:402.53
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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CNS-Penetrant Compound Library
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Biologische Aktivität
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AChE 0.176 μM (IC50) |
BChE 0.47 μM (IC50) |
AChE/BChE-IN-10 inhibits AChE in a non-competitive manner with Ki of 0.21 μM, and BChE in a mixed-fashion with Ki of 0.15 μM[1].
AChE/BChE-IN-10 shows BBB permeability (Pe) value of 6.9 × 10-6 (>3.3 × 10-6 cm/s) cm/s falls[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2924824-48-4
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Appearance Solid
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Molecular Weight 402.53
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Formel C26H30N2O2
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Color White to off-white
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SMILES
O=C(NCCC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C4C=C(OC)C=CC4=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (62.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4843 mL | 12.4214 mL | 24.8429 mL | 62.1072 mL |
| 5 mM | 0.4969 mL | 2.4843 mL | 4.9686 mL | 12.4214 mL | |
| 10 mM | 0.2484 mL | 1.2421 mL | 2.4843 mL | 6.2107 mL | |
| 15 mM | 0.1656 mL | 0.8281 mL | 1.6562 mL | 4.1405 mL | |
| 20 mM | 0.1242 mL | 0.6211 mL | 1.2421 mL | 3.1054 mL | |
| 25 mM | 0.0994 mL | 0.4969 mL | 0.9937 mL | 2.4843 mL | |
| 30 mM | 0.0828 mL | 0.4140 mL | 0.8281 mL | 2.0702 mL | |
| 40 mM | 0.0621 mL | 0.3105 mL | 0.6211 mL | 1.5527 mL | |
| 50 mM | 0.0497 mL | 0.2484 mL | 0.4969 mL | 1.2421 mL | |
| 60 mM | 0.0414 mL | 0.2070 mL | 0.4140 mL | 1.0351 mL |
AChE/BChE-IN-10 Related Classifications
HY-151368 Related Classifications
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