Androst-16-en-3-ol
Androst-16-en-3-ol is a pheromone derived from boars that triggers mating responses in estrous sows. It also exists in human urine, plasma, saliva and sweat. As an endogenous neurosteroid, Androst-16-en-3-ol acts as a positive allosteric modulator of GABAA receptors (GABAA receptor) and exerts anxiolytic, antidepressant and anticonvulsant activities in mice.
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- CAS. Nr.: 7148-51-8
- Formel: C19H30O
- Molecular Weight:274.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Androstenol (15-20 s preapplication and coapplication with GABA) positively modulates GABAA receptors in mouse cerebellar slices with an EC50 of 1.4 μM, enhancing GABA-activated currents in a concentration-dependent manner[1].
Androstenol (0.1-300 μM) potentiates GABAA receptors in HEK 293 cells transfected with α1β2γ2 or α2β2γ2 subunits at 0.1-1 μM and directly activates these receptors at 10-300 μM[1].
Androstenol prolongs the duration of spontaneous inhibitory postsynaptic currents in mouse cultured cerebellar granule cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Androst-16-en-3-ol (5-10 mg/kg; i.p.; single dose) exhibits antidepressant-like effects in mice in the forced swim test[1].
Androst-16-en-3-ol (10-100 mg/kg; i.p.; single dose 15 minutes before seizure induction) has anticonvulsant activity in mice[1].
Androst-16-en-3-ol (100-300 mg/kg; i.p.; single dose) causes motor impairment in mice at high doses with a TD50 of 181 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NIH Swiss (male, 25-30 g)[1]
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Dosage:10, 30, 50, 100 mg/kg
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Administration:i.p.; single dose immediately before testing
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Result:Significantly increased the area-under-the-curve for percent time spent in the center of the arena at 30 and 50 mg/kg.
Reduced horizontal activity at 100 mg/kg, making center time values unmeaningful.
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Animal Model:NIH Swiss (male, 25-30 g)[1]
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Dosage:10, 30, 50 mg/kg
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Administration:i.p.; single dose 15 minutes before testing
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Result:Caused a dose-dependent reduction in latency to first open arm entry, increase in number of open arm entries, and increase in percent time spent in open arms; observed significant effects at doses of 10-50 mg/kg depending on the measure.
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Animal Model:NIH Swiss (male, 25-30 g)[1]
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Dosage:5, 10, 30 mg/kg
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Administration:i.p.; single dose 15 minutes before testing
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Result:Reduced immobility times compared with vehicle at 5 and 10 mg/kg; showed no activity at 30 mg/kg.
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Animal Model:NIH Swiss (male, 25-30 g)[1]
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Dosage:10, 30, 100 mg/kg
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Administration:i.p.; single dose 15 minutes before seizure induction
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Result:Conferred dose-dependent protection against seizures in both pentylenetetrazol and 6 Hz electroshock models; reached ED50 values of 21.9 mg/kg (6 Hz model) and 48.9 mg/kg (pentylenetetrazol model).
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Animal Model:NIH Swiss (male, 25-30 g)[1]
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Dosage:100, 200, 300 mg/kg
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Administration:i.p.; single dose 15 minutes before testing
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Result:Caused no impairment at 100 mg/kg; impaired 4/6 mice at 200 mg/kg and 5/6 at 300 mg/kg; reached a TD50 value of 181 mg/kg.
Chemical Information
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CAS. Nr. 7148-51-8
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Molecular Weight 274.44
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Formel C19H30O
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C=CC4)C
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Synonyms
3β-Androstenol
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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