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Art. -Nr.: HY-125258

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EBOV-IN-11

EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with K_d values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection.

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CAS. Nr.: 752216-12-9
Formel: C₂₆H₂₅N₃O₆
Molecular Weight:475.50

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Please store the product under the recommended conditions in the Certificate of Analysis.

EBOV-IN-11 Chemical Structure

CAS. Nr.: 752216-12-9

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Biologische Aktivität
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Chemical Information
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Biologische Aktivität

Beschreibung

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In Vitro

EBOV-IN-11 (Compound C31) (10 μM; 3 d) inhibits the replication of EBOV-eGFP in Vero E6 cells with low initial cytotoxicity^[1].
EBOV-IN-11 (100 μM) exhibits <30% cytotoxicity in 293T cells, while it shows no cytotoxicity in PBMCs^[1].
EBOV-IN-11 (1-30 μM; 49 h) potently inhibits EBOV replication in Vero E6 cells at concentrations of 3 μM and above, reducing viral titers by 2-3 orders of magnitude^[1].
EBOV-IN-11 (10 μM; 48 h) inhibits the transcription of EBOV minigenome in 293T cells, with inhibitory potency comparable to that of 1E7-03^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 752216-12-9
Molecular Weight 475.50
Formel C₂₆H₂₅N₃O₆
SMILES

O=C(OC(C(=O)NC(=O)N)C)C=1C=2C=CC=CC2N=C3C(=CC4=CC=C(OC)C(OC)=C4)CCC31
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ammosova T, et al. Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication. J Infect Dis. 2018;218(suppl_5):S627-S635. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EBOV-IN-11

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