eEF2K degrader-2
eEF2K degrader-2 (Compound C1) is a molecular glucose degrading agent that targets the eEF2K protein. eEF2K degrader-2 can significantly inhibit the proliferation, migration, invasion and induce apoptosis of triple negative breast cancer (TNBC) cells. eEF2K degrader-2 has no obvious organ toxicity or pathological damage. eEF2K degrader-2 can be used in the research of cancer such as breast cancer.
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- CAS. Nr.: 1044797-96-7
- Formel: C27H29FN4O5
- Molecular Weight:508.54
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | IC50 |
131.2 nM
Compound: C1
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Antitumor activity against human MDA-MB-231 cells assessed as inhibition of cell viability by measuring inhibition rate measured after 72 hrs by CCK-8 assay relative to control
Antitumor activity against human MDA-MB-231 cells assessed as inhibition of cell viability by measuring inhibition rate measured after 72 hrs by CCK-8 assay relative to control
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[PMID: 39208364] |
Chemical Information
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CAS. Nr. 1044797-96-7
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Molecular Weight 508.54
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Formel C27H29FN4O5
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SMILES
FC1=CC(CN(C2=O)C(C(C(N3CC(C(OCC)=O)CCC3)=O)=NN2C4=CC=C(C(C)=C4)C)=O)=CC=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
eEF2K degrader-2 Related Classifications
HY-177720 Related Classifications
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