TSEN15 - tRNA splicing endonuclease subunit 15 Gene

Also Known as PCH2F; sen15; C1orf19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116461

About TSEN15

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:184,051,730-184,097,485 (from NCBI)

This gene has 20 transcripts (splice variants), 191 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 5.4), brain (RPKM 4.2) and 25 other tissues.

Summary

This gene encodes a subunit of the tRNA splicing Endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]

TSEN15 Products (5)

mRNA	Protein	Name
NM_001127394.4	NP_001120866.1	tRNA-splicing endonuclease subunit Sen15 isoform 2
NM_001300764.2	NP_001287693.1	tRNA-splicing endonuclease subunit Sen15 isoform 3
NM_001300766.2	NP_001287695.1	tRNA-splicing endonuclease subunit Sen15 isoform 4
NM_001363643.2	NP_001350572.1	tRNA-splicing endonuclease subunit Sen15 isoform 5
NM_052965.4	NP_443197.1	tRNA-splicing endonuclease subunit Sen15 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSEN15 Protein Structure

Sen15

0
100
171 a.a.

Protein Preferred Names	Protein Names
tRNA-splicing endonuclease subunit Sen15	TSEN15 tRNA splicing endonuclease subunit

TSEN15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TSEN15	Q8WW01	DNAAF6	Homo sapiens	Q9NQM4	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	DNAAF6	Homo sapiens	Q9NQM4	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	DNAAF6	Homo sapiens	Q9NQM4	Y2H Array	32296183
Intra	TSEN15	Q8WW01	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	TSEN15	Q8WW01	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	PLB1	Homo sapiens	Q6P1J6-2	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	PLB1	Homo sapiens	Q6P1J6-2	Y2H Array	32296183
Intra	TSEN15	Q8WW01	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	TSEN15	Q8WW01	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	TSEN15	Q8WW01	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	TSEN15	Q8WW01	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	TSEN15	Q8WW01	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	TSEN15	Q8WW01	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	TSEN15	Q8WW01	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	AIF1L	Homo sapiens	Q9BQI0-4	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	AIF1L	Homo sapiens	Q9BQI0-4	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	AIF1L	Homo sapiens	Q9BQI0-4	Y2H Array	32296183
Intra	TSEN15	Q8WW01	ASB12	Homo sapiens	Q8WXK4-2	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	ASB12	Homo sapiens	Q8WXK4-2	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	ASB12	Homo sapiens	Q8WXK4-2	Y2H Array	32296183
Intra	TSEN15	Q8WW01	ZNF554	Homo sapiens	Q86TJ5	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	ZNF554	Homo sapiens	Q86TJ5	Y2H Array	32296183
Intra	TSEN15	Q8WW01	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	TSEN15	Q8WW01	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	TSEN15	Q8WW01	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	32296183
Intra	TSEN15	Q8WW01	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	TSEN15	Q8WW01	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	TSEN15	Q8WW01	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32296183
Intra	TSEN15	Q8WW01	LRIF1	Homo sapiens	Q5T3J3	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	TSEN15	Q8WW01	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	TSEN15	Q8WW01	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	TSEN15	Q8WW01	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	TSEN15	Q8WW01	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	ENKD1	Homo sapiens	Q9H0I2	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	ENKD1	Homo sapiens	Q9H0I2	Y2H Array	32296183
Intra	TSEN15	Q8WW01	TASOR2	Homo sapiens	Q5VWN6	Y2H Array	32296183
Intra	TSEN15	Q8WW01	TASOR2	Homo sapiens	Q5VWN6	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	TSEN15	Q8WW01	TSSK2	Homo sapiens	Q96PF2	Validated Y2H	32296183
Intra	TSEN15	Q8WW01	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	TSEN15	Q8WW01	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pontocerebellar Hypoplasia, Type 2f	PCH2F Pontocerebellar Hypoplasia Type 2f Pontocerebellar Hypoplasia 2f Doid:0112329 Hypoplasia, Pontocerebellar, Type 2f
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Acromesomelic Dysplasia 2b	Fibular Hypoplasia And Complex Brachydactyly Du Pan Syndrome AMD2B Dupans Acromesomelic Dysplasia-2b Fibular Aplasia-Complex Brachydactyly Syndrome
Pontocerebellar Hypoplasia, Type 1d	PCH1D Pontocerebellar Hypoplasia Type 1d Pontocerebellar Hypoplasia 1d Doid:0112323 Hypoplasia, Pontocerebellar, Type 1d
Pontocerebellar Hypoplasia, Type 4	Pontocerebellar Hypoplasia Type 4 PCH4 Olivopontocerebellar Hypoplasia Encephalopathy Fatal Infantile With Olivopontocerebellar Hypoplasia Encephalopathy, Fatal Infantile, With Olivopontocerebellar Hypoplasia Fatal Infantile Encephalopathy With Olivopontocerebellar Hypoplasia Pontocerebellar Hypoplasia 4 Young Mckeever Squier Syndrome Hypoplasia, Pontocerebellar, Type 4
Pontocerebellar Hypoplasia, Type 10	Pontocerebellar Hypoplasia Type 10 PCH10 Clp1-Related Pontocerebellar Hypoplasia Pontocerebellar Hypoplasia 10 Hypoplasia, Pontocerebellar, Type 10
Immunodeficiency 36	IMD36 Activated Phosphoinositide 3-Kinase Delta Syndrome 2 Immunodeficiency, Type 36
Pontocerebellar Hypoplasia, Type 3	Pontocerebellar Hypoplasia Type 3 Cerebellar Atrophy With Progressive Microcephaly PCH3 Clam Pch With Optic Atrophy Pontocerebellar Hypoplasia 3 Hypoplasia, Pontocerebellar, Type 3
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15137	TSEN15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSEN15	MGD	MGI:1913887
Felis catus	TSEN15	VGNC	VGNC:107958
Bos taurus	TSEN15	VGNC	VGNC:36410
Macaca mulatta	TSEN15	VGNC	VGNC:106525
Rattus norvegicus	TSEN15	RGD	RGD:1308584
Canis familiaris	TSEN15	VGNC	VGNC:47895
Others	TSEN15	NCBI