TSSK2 - testis specific serine kinase 2 Gene

Also Known as TSK2; DGS-G; SPOGA2; STK22B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23617

About TSSK2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:19,131,308-19,132,622 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues and 17 paralogues.

Summary

TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

TSSK2 Products (1)

mRNA Protein Name
NM_053006.5 NP_443732.3 testis-specific serine/threonine-protein kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables magnesium ion binding IDA
IDA: Inferred from direct assay
20729278 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15044604 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18533145 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
20729278 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSSK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (17 - 272)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

testis-specific serine/threonine-protein kinase 2

  • TSK-2

TSSK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSSK2 Q96PF2 FAM229B Homo sapiens Q4G0N7
Y2H Prey Pooling
32296183
Intra
TSSK2 Q96PF2 FAM229B Homo sapiens Q4G0N7
Y2H Array
32296183
Intra
TSSK2 Q96PF2 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
TSSK2 Q96PF2 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
TSSK2 Q96PF2 TSEN15 Homo sapiens Q8WW01
Y2H Array
32296183
Intra
TSSK2 Q96PF2 TSEN15 Homo sapiens Q8WW01
Y2H Prey Pooling
32296183
Intra
TSSK2 Q96PF2 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
TSSK2 Q96PF2 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
TSSK2 Q96PF2 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Y2H Prey Pooling
32296183
Intra
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Pull Down
15044604
Intra
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Y2H Array
32296183
Intra
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2
Validated Y2H
32296183
Intra
TSSK2 Q96PF2 TSKS Homo sapiens Q9UJT2-2
Protein Kinase Assay
15044604
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hyperprolinemia, Type I

  • Proline Oxidase Deficiency

  • Hyperprolinemia Type 1

  • HYRPRO1

  • Hpi

  • Hyperprolinemia Type I

  • Hyperprolinemia 1

  • Proline Dehydrogenase Deficiency
Digeorge Syndrome

  • Chromosome 22q11.2 Deletion Syndrome

  • DGS

  • Hypoplasia Of Thymus And Parathyroids

  • Third And Fourth Pharyngeal Pouch Syndrome

  • 22q11.2 Deletion Syndrome

  • Digeorge Sequence

  • Digeorge'S Syndrome

  • Pharyngeal Pouch Syndrome

  • Di-George Syndrome

  • Shprintzen Syndrome
Van Den Ende-Gupta Syndrome

  • VDEGS

  • Blepharophimosis, Arachnodactyly, And Congenital Contractures

  • Marden-Walker-Like Syndrome

  • Marden-Walker-Like Syndrome Without Psychomotor Retardation

  • Marden Walker Like Syndrome

  • Marden-Walker-Like Syndrome Without Psychmotor Retardation

  • Van Den Ende Gupta Syndrome

  • Marden Walker Like Syndrome Without Psychomotor Retardation

  • Blepharophimosis Arachnodactyly And Congenital Contractures
Combined D-2- And L-2-Hydroxyglutaric Aciduria

  • D,L-2-Hydroxyglutaric Aciduria

  • D2L2AD

  • Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia

  • Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria

  • D,L-2-Hga

  • D,L-2-Hydroxyglutaric Acidemia

  • Combined D,L-2-Hydroxyglutaric Aciduria
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15358 ALK inhibitor 2 Inhibitor 99.72% Unkown
HY-15357 ALK inhibitor 1 Inhibitor 99.16% Unkown
HY-184429 TSSK1 ligand-1 Ligand / Unkown
HY-RS15188 TSSK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17426 Tssk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23881 Tssk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TSSK2 VGNC VGNC:78557
Mus musculus TSSK2 MGD MGI:1347559
Felis catus TSSK2 VGNC VGNC:66644
Rattus norvegicus TSSK2 RGD RGD:1304951
Canis familiaris TSSK2 VGNC VGNC:103714
Bos taurus TSSK2 VGNC VGNC:49975
Others TSSK2 NCBI