TSKS - testis specific serine kinase substrate Gene

Also Known as TSKS1; TSSKS; STK22S1; PPP1R161

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60385

About TSKS

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,739,760-49,763,306 (from NCBI)

This gene has 3 transcripts (splice variants) and 101 orthologues. Restricted expression toward testis (RPKM 31.5).

Summary

This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular Cancer. The gene is localized to the region 19q13.3 among the related Ras viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

TSKS Products (1)

mRNA Protein Name
NM_021733.2 NP_068379.1 testis-specific serine kinase substrate

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15044604 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18533145 GOA
Cellular Component GO Annotation Evidence References Source
located in centriole IDA
IDA: Inferred from direct assay
18495105 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSKS Protein Structure

TSKS

TSKS: Testis-specific serine kinase substrate (26 - 592)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

testis-specific serine kinase substrate

  • STK22 substrate 1

TSKS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSKS Q9UJT2 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
TSKS Q9UJT2 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
TSKS Q9UJT2 TPM3 Homo sapiens P06753
Y2H Array
32296183
Intra
TSKS Q9UJT2 TPM3 Homo sapiens P06753
Y2H Prey Pooling
32296183
Intra
TSKS Q9UJT2 TSSK1B Homo sapiens Q9BXA7
Y2H Array
32296183
Intra
TSKS Q9UJT2 TSSK1B Homo sapiens Q9BXA7
Y2H Prey Pooling
32296183
Intra
TSKS Q9UJT2 TSSK2 Homo sapiens Q96PF2
Y2H Array
32296183
Intra
TSKS Q9UJT2 TSSK2 Homo sapiens Q96PF2
Y2H
15044604
Intra
TSKS Q9UJT2 TSSK2 Homo sapiens Q96PF2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991913 CID-103 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N18085 Procyanidin B1 3'-O-gallate / Unkown
HY-RS15151 TSKS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TSKS VGNC VGNC:47906
Bos taurus TSKS VGNC VGNC:36421
Rattus norvegicus TSKS RGD RGD:727784
Felis catus TSKS VGNC VGNC:66620
Macaca mulatta TSKS VGNC VGNC:79868
Mus musculus TSKS MGD MGI:1347560
Others TSKS NCBI