XRCC5 - X-ray repair cross complementing 5 Gene

Also Known as KU80; KUB2; Ku86; NFIV; KARP1; KARP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7520

About XRCC5

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:216,109,348-216,206,293 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 87.8), lymph node (RPKM 70.4) and 25 other tissues.

Summary

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA Ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with Cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

XRCC5 Products (1)

mRNA	Protein	Name
NM_021141.4	NP_066964.1	X-ray repair cross-complementing protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
contributes to 5'-deoxyribose-5-phosphate lyase activity	IMP IMP: Inferred from mutant phenotype	20383123	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	9368068	GOA
enables ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	9368068	GOA
contributes to DNA end binding	IDA IDA: Inferred from direct assay	9368068	GOA
enables DNA end binding	IDA IDA: Inferred from direct assay	19549901	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	14704337	GOA
enables U3 snoRNA binding	IDA IDA: Inferred from direct assay	32103174	GOA
contributes to double-stranded telomeric DNA binding	IDA IDA: Inferred from direct assay	10409678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8621488	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12377759	GOA
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	10535943	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18809223	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22266820	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27248496	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	26359349	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	19581589	GOA
involved in double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	26359349	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	20383123	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	8621488	GOA
involved in negative regulation of t-circle formation	IMP IMP: Inferred from mutant phenotype	19581589	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	22504299	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	19188702	GOA
involved in regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	25852083	GOA
involved in small-subunit processome assembly	IDA IDA: Inferred from direct assay	32103174	GOA
involved in telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	19188702	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of DNA-dependent protein kinase complex	IPI IPI: Inferred from physical interaction	28840859	GOA
part of DNA-dependent protein kinase-DNA ligase 4 complex	IDA IDA: Inferred from direct assay	34352203	GOA
part of Ku70:Ku80 complex	IDA IDA: Inferred from direct assay	20383123	GOA
part of Ku70:Ku80 complex	IPI IPI: Inferred from physical interaction	11493912	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	10535943	GOA
part of nonhomologous end joining complex	IDA IDA: Inferred from direct assay	20383123	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	32103174	GOA
located in nucleus	IDA IDA: Inferred from direct assay	32103174	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	22504299	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22504299	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	14704337	GOA
located in site of DNA damage	IMP IMP: Inferred from mutant phenotype	27248496	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	32103174	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRCC5 Protein Structure

Ku_N

Ku_C

Ku_PK_bind

0
200
400
600
732 a.a.

Protein Preferred Names	Protein Names
X-ray repair cross-complementing protein 5	86 kDa subunit of Ku antigen

XRCC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	XRCC5	P13010	HOXB7	Homo sapiens	P09629	Anti Bait CoIP	17308091
Intra	XRCC5	P13010	APLF	Homo sapiens	Q8IW19	Y2H	23178593
Intra	XRCC5	P13010	TPT1	Homo sapiens	P13693	Anti Bait CoIP	22451927
Intra	XRCC5	P13010	PAXX	Homo sapiens	Q9BUH6	Anti Bait CoIP	25574025
Intra	XRCC5	P13010	PRKDC	Homo sapiens	P78527	Anti Bait CoIP	17308091
Intra	XRCC5	P13010	PRKDC	Homo sapiens	P78527	Anti Tag CoIP	26496610
Intra	XRCC5	P13010	PRKDC	Homo sapiens	P78527	Anti Bait CoIP	20085707
Intra	XRCC5	P13010	HSPB1	Homo sapiens	P04792	Anti Bait CoIP	25277244
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	10783163
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	TAP	24981860
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Crosslink	30021884
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	22451927
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	26496610
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	17308091
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	TAP	21679440
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Y2H Array	32296183
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Y2H Prey Pooling	32296183
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	21070772
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Biochemical	17159921
Intra	XRCC5	P13010	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	XRCC5	P13010	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	XRCC5	P13010	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	XRCC5	P13010	COIL	Homo sapiens	P38432	Anti Bait CoIP	21070772

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant XRCC5 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P73846	Ku70-Ku80 Heterodimer Protein, Human (sf9, His)	P13010 (M1-I732)&P12956 (M1-D609)	≥ 90%, as determined by reducing SDS-PAGE.

XRCC5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80203	Ku80 Antibody (YA318)	WB, ICC/IF, IHC-P, IP	Human
HY-P80737	Ku80 Antibody (YA714)	WB, ICC/IF, IP, ChIP	Human, Monkey
HY-P80737A	Ku80 Antibody (YA714)(PBS only)	WB, ICC/IF, IP, ChIP	Human, Monkey
HY-P84079	Ku80 Antibody (YA3776)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84079A	Ku80 Antibody (YA3776)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P85251	Ku80 Antibody (YA4943)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue	Human
HY-P85599	Ku80 Antibody (YA5291)	WB, ICC/IF, IP	Human, Monkey

Related Diseases

Diseases	Alias
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Viral Exanthem	Viral Rash Nos Virus Exanthema Nonspecific Exanthematous Viral Infection Nonspecific Viral Exanthem Nonspecific Viral Rash Viral Enanthema Nos Viral Disease Characterised By Exanthem Viral Exanthemata Viral Exanthem, Unspecified Viral Exanthema Nos
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Erythema Infectiosum	Fifth Disease Slapped Cheek Syndrome Parvovirus B19 Infection
Lig4 Syndrome	Dna Ligase Iv Deficiency Ligase 4 Syndrome LIG4S
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Hemangioma Of Subcutaneous Tissue	Angioma Of The Subcutaneous Tissue Subcutaneous Haemangioma Subcutaneous Hemangioma
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation	Severe Combined Immunodeficiency, Athabascan Type Severe Combined Immunodeficiency Due To Dclre1c Deficiency Rs-Scid Scid, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, With Sensitivity To Ionizing Radiation Scid Due To Artemis Deficiency Scid Due To Dclre1c Deficiency Scid, Athabascan Type Scid, Athabaskan Type Severe Combined Immunodeficiency Due To Artemis Deficiency Severe Combined Immunodeficiency, Athabaskan Type SCIDA Severe Combined Immunodeficiency, Athabascan-Type Artemis Deficiency Severe Combined Immunodeficiency Athabaskan Type Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Negative/Nk-Cell-Positive With Sensitivity To Ionizing Radiation RSSCID Athabascan Scid Immunodeficiency, Severe Combined, Athabascan Type Severe Combined Immunodeficiency, Athabaskan-Type
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Autosomal Recessive Cerebellar Ataxia	Arca
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15900	XRCC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22924	Xrcc5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29438	Xrcc5 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	XRCC5	RGD	RGD:3976
Bos taurus	XRCC5	VGNC	VGNC:37006
Macaca mulatta	XRCC5	VGNC	VGNC:99422
Canis familiaris	XRCC5	VGNC	VGNC:48469
Felis catus	XRCC5	VGNC	VGNC:67120
Mus musculus	XRCC5	MGD	MGI:104517
Others	XRCC5	NCBI