APLF - aprataxin and PNKP like factor Gene

Also Known as APFL; PALF; Xip1; ZCCHH1; C2orf13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 200558

About APLF

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,467,585-68,580,162 (from NCBI)

This gene has 6 transcripts (splice variants) and 180 orthologues. Ubiquitous expression in testis (RPKM 1.6), skin (RPKM 1.2) and 24 other tissues.

Summary

C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]

APLF Products (1)

mRNA Protein Name
NM_173545.3 NP_775816.1 aprataxin and PNK-like factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' exonuclease activity IDA
IDA: Inferred from direct assay
17396150 GOA
enables ADP-D-ribose modification-dependent protein binding IDA
IDA: Inferred from direct assay
18172500 GOA
enables DNA endonuclease activity IDA
IDA: Inferred from direct assay
17396150 GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
IDA: Inferred from direct assay
17396150 GOA
enables histone binding IDA
IDA: Inferred from direct assay
21211722 GOA
enables histone chaperone activity IDA
IDA: Inferred from direct assay
21211722 GOA
enables nucleotide binding IDA
IDA: Inferred from direct assay
18172500 GOA
enables poly-ADP-D-ribose binding IDA
IDA: Inferred from direct assay
18172500 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17353262 GOA
enables protein folding chaperone EXP
EXP: Inferred from Experiment
29905837 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
17396150 GOA
involved in DNA repair IDA
IDA: Inferred from direct assay
21211722 GOA
involved in DNA repair-dependent chromatin remodeling IDA
IDA: Inferred from direct assay
21211722 GOA
involved in double-strand break repair IMP
IMP: Inferred from mutant phenotype
17396150 GOA
involved in double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
23689425 GOA
acts upstream of or within positive regulation of DNA ligation IGI
IGI: Inferred from genetic interaction
21211721 GOA
involved in protein localization to chromatin IDA
IDA: Inferred from direct assay
21211722 GOA
involved in single strand break repair IMP
IMP: Inferred from mutant phenotype
17396150 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17396150 GOA
is active in site of DNA damage IDA
IDA: Inferred from direct assay
30104678 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
21211722 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
23689425 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
21211721 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APLF Protein Structure

zf-CCHH

zf-CCHH: Zinc-finger (CX5CX6HX5H) motif (377 - 402)

zf-CCHH

zf-CCHH: Zinc-finger (CX5CX6HX5H) motif (419 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 511 a.a.
Protein Preferred Names Protein Names

aprataxin and PNK-like factor

  • PNK and APTX-like FHA domain-containing protein

APLF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
APLF Q8IW19 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra
APLF Q8IW19 FLJ13057 Homo sapiens Q53SE7
Y2H Array
25416956
Intra
APLF Q8IW19 PARP2 Homo sapiens Q9UGN5
Anti Tag CoIP
33961781
Intra
APLF Q8IW19 PARP1 Homo sapiens P09874
Anti Tag CoIP
33961781
Intra
APLF Q8IW19 PARP1 Homo sapiens P09874
Anti Tag CoIP
28514442
Intra
APLF Q8IW19 PARP1 Homo sapiens P09874
Enzymatic Study
18172500
Intra
APLF Q8IW19 PARP1 Homo sapiens P09874
Pull Down
17396150
Intra
APLF Q8IW19 PARP1 Homo sapiens P09874
Anti Tag CoIP
18172500
Intra
APLF Q8IW19 PARP1 Homo sapiens P09874
Anti Tag CoIP
20098424
Intra
APLF Q8IW19 XRCC5 Homo sapiens P13010
Pull Down
17396150
Intra
APLF Q8IW19 XRCC5 Homo sapiens P13010
Anti Tag CoIP
20098424
Intra
APLF Q8IW19 XRCC5 Homo sapiens P13010
Y2H
23178593
Intra
APLF Q8IW19 XRCC5 Homo sapiens P13010
FPS
23178593
Intra
APLF Q8IW19 XRCC5 Homo sapiens P13010
Filter Binding
23178593
Intra
APLF Q8IW19 XRCC5 Homo sapiens P13010
Anti Tag CoIP
33961781
Intra
APLF Q8IW19 XRCC5 Homo sapiens P13010
Anti Tag CoIP
28514442
Intra
APLF Q8IW19 XRCC4 Homo sapiens Q13426
Anti Tag CoIP
33961781
Intra
APLF Q8IW19 XRCC4 Homo sapiens Q13426
Y2H
17353262
Intra
APLF Q8IW19 XRCC4 Homo sapiens Q13426
Filter Binding
23178593
Intra
APLF Q8IW19 XRCC4 Homo sapiens Q13426
Pull Down
17396150
Intra
APLF Q8IW19 XRCC4 Homo sapiens Q13426
Anti Tag CoIP
28514442
Intra
APLF Q8IW19 LIG4 Homo sapiens P49917
Pull Down
17396150
Intra
APLF Q8IW19 LIG4 Homo sapiens P49917
Anti Tag CoIP
33961781
Intra
APLF Q8IW19 LIG4 Homo sapiens P49917
Anti Tag CoIP
28514442
Intra
APLF Q8IW19 LIG4 Homo sapiens P49917
Filter Binding
23178593
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
Y2H
17353262
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
Anti Tag CoIP
17353262
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
Filter Binding
17353262
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
Y2H
23178593
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
Anti Tag CoIP
33961781
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
Pull Down
17396150
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
Anti Tag CoIP
28514442
Intra
APLF Q8IW19 XRCC1 Homo sapiens P18887
IF
17353262
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

  • CONDSIAS

  • Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Inhalation Anthrax

  • Pulmonary Anthrax

  • Respiratory Anthrax

  • Inhalational Anthrax

  • Wool-Sorters' Disease

  • Woolsorters' Disease

  • Inhalation Anthrax Disease

  • Respiratory Anthrax Disease
Osgood-Schlatter'S Disease

  • Osgood-Schlatter Disease

  • Juvenile Osteochondrosis Of Tibial Tubercle

  • Osteochondrosis

  • Osteochondritis Of Tibial Tubercle

  • Osteochondrosis Of Proximal Tibia

  • Aseptic Necrosis Of The Tibial Tubercle

  • Osteochondrosis Of The Tibial Tubercle

  • Osteochondritis Juvenilis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00821 APLF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22105 Aplf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28626 Aplf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus APLF VGNC VGNC:59203
Macaca mulatta APLF VGNC VGNC:106127
Felis catus APLF VGNC VGNC:79992
Mus musculus APLF MGD MGI:1919353
Rattus norvegicus APLF RGD RGD:1565557
Canis familiaris APLF VGNC VGNC:53960
Others APLF NCBI