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Art. -Nr.: HY-184104

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IDO1/TDO-IN-17

IDO1/TDO-IN-17 is an IDO1/TDO inhibitor with human IDO1 IC₅₀ ~280 μmol/L and human TDO IC₅₀ 204 μmol/L. IDO1/TDO-IN-17 binds to the heme-iron of IDO1. IDO1/TDO-IN-17 can be used for the research of cancer.

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CAS. Nr.: 537010-02-9
Formel: C₁₅H₁₄N₂O₃S
Molecular Weight:302.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDO1/TDO-IN-17 Chemical Structure

CAS. Nr.: 537010-02-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IDO1

~280 μM (IC₅₀)

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen :

In Vitro

IDO1/TDO-IN-17 (Compound 19) inhibits recombinant human IDO1 with an IC₅₀ of ~280 μmol/L and recombinant human TDO with an IC₅₀ of 204 μmol/L, binding to the heme-iron of hIDO1 but not hTDO^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 537010-02-9
Molecular Weight 302.35
Formel C₁₅H₁₄N₂O₃S
SMILES

O=S(O)(C1=NC2=C(N1C(C)C3=CC=CC=C3)C=CC=C2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dai Q, et al. AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases. Acta Pharm Sin B. 2021;11(7):1931-1946. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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IDO1/TDO-IN-17

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

IDO1/TDO-IN-17 Related Classifications

HY-184104 Related Classifications