IDO1/TDO-IN-8
IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor that can penetrate the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. IDO1/TDO-IN-8 reduces the kynurenine/tryptophan ratio by regulating the kynurenine pathway of tryptophan metabolism. IDO1/TDO-IN-8 has a neuroprotective effect and can alleviate motor dysfunction and improve depressive behavior. IDO1/TDO-IN-8 can be used in the study of Parkinson's disease combined with depression.
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- CAS. Nr.: 3085413-22-2
- Formel: C17H14N2S
- Molecular Weight:278.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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IDO1 0.33 μM (EC50) |
Chemical Information
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CAS. Nr. 3085413-22-2
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Molecular Weight 278.37
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Formel C17H14N2S
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SMILES
CC1=CC(C2=NC=CC3=C2NC4=C3C=CC=C4)=C(C)S1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IDO1/TDO-IN-8 Related Classifications
HY-173513 Related Classifications
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