Myrcene-13C3
Myrcene-13C3 is 13C labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity.
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- CAS. Nr.: 3028870-47-2
- Formel: C713C3H16
- Molecular Weight:139.21
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Myrcene (50 μM, 100 μM; 24 h, 48 h) inhibits 10 ng/mL TNFα-induced NF-κB activity, through causing the inactivation of IKK in MDA-MB-231 cells[3].
Myrcene (0.25-1.0 μg/mL; 24 h, 48 h) inhibits clonal sphere formation in A549 cells, and arrests cell cycle in the G0/G1 phases to cause apoptosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 3028870-47-2
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Unlabeled Cas 123-35-3
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Molecular Weight 139.21
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Formel C713C3H16
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SMILES
C=CC(CC/C=[13C]([13CH3])/[13CH3])=C
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Synonyms
β-Myrcene-13C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Eunson Hwang, et al. Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production. Am J Chin Med. 2017;45(5):1113-1124. [Content Brief]
[5]. Islam AUS, et al. Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model. Molecules. 2020 Sep 30;25(19):4492. [Content Brief]
[6]. Kumar R, et al. Ameliorative effect of myrcene in mouse model of Alzheimer's disease. Eur J Pharmacol. 2021 Nov 15;911:174529. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Myrcene-13C3 Related Classifications
HY-N0803S1 Related Classifications
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