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Art. -Nr.: HY-N11777

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(−)-N-Hydroxyapiosporamide

(Synonyms: NHAP)

(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC).

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CAS. Nr.: 1205676-02-3
Formel: C₂₄H₃₁NO₇
Molecular Weight:445.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(−)-N-Hydroxyapiosporamide Chemical Structure

CAS. Nr.: 1205676-02-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.93 μM Compound: NHAP	Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
HCT-116	IC₅₀	2.8 μM Compound: NHAP	Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37243616]
HCT-15	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
HT-29	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
HT-29	IC₅₀	0.61 μM Compound: NHAP	Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay	[PMID: 37243616]
RKO	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
SW480	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]
SW-620	IC₅₀	0.57 μM Compound: NHAP	Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay	[PMID: 37243616]

Chemical Information

CAS. Nr. 1205676-02-3
Molecular Weight 445.51
Formel C₂₄H₃₁NO₇
SMILES

O=C([C@]1([C@]2([C@@]([H])(C[C@@H](CC2)C)C=C[C@H]1C)[H])[H])C3=C(C([C@@]4([C@H]5[C@@H]([C@@H](CC4)O)O5)O)=CN(O)C3=O)O
Synonyms

NHAP
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
- Microorganisms
Apiospora montagnei
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Feng L, et al. The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex. J Nat Prod. 2023 Jun 23;86(6):1449-1462. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

(−)-N-Hydroxyapiosporamide

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(−)-N-Hydroxyapiosporamide

Alle NF-κB Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

(−)-N-Hydroxyapiosporamide Related Classifications

HY-N11777 Related Classifications