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Art. -Nr.: HY-187336

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Nampt-IN-22

Nampt-IN-22 is a nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-22 blocks the NAD⁺ salvage synthesis pathway by inhibiting nicotinamide phosphoribosyltransferase (NAMPT). Its tertiary alcohol forms hydrogen bonds with His191 of NAMPT and enhances lysosomal stability via intramolecular hydrogen bonds. As an ADC payload, Nampt-IN-22 exhibits low nanomolar cytotoxicity against tumor cells after conjugation to an anti-CD30 antibody, prolongs survival in a disseminated L540 Hodgkin lymphoma mouse model, and suppresses subcutaneous tumor growth. Nampt-IN-22 can be used in studies related to Hodgkin lymphoma.

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CAS. Nr.: 3087291-80-0
Formel: C₂₃H₂₉N₇O₂
Molecular Weight:435.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nampt-IN-22 Chemical Structure

CAS. Nr.: 3087291-80-0

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Nampt-IN-22 (compound 3) (24 h) exhibits partial resistance to acid-induced hydration into inactive guanylurea metabolites, with only 23% conversion observed after treatment at pH < 2 and 37°C^[1].
Nampt-IN-22 (72 h) produces no detectable levels of the inactive guanidino urea metabolite after incubation with human liver lysosomal extracts at 37°C, indicating its resistance to enzyme-driven lysosomal conversion^[1].
Free Nampt-IN-22 (0.0001-10 µM; 96 h) inhibits the viability of CD30-positive human Hodgkin's lymphoma L540 cells, with an IC₅₀ of 0.1395 µM, and achieves complete cell killing at high concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt-IN-22 (conjugated to anti-CD30 antibody, DAR10) (administered intravenously; once weekly for 4 weeks, or as a single dose) (6.25-12.5 mg/kg; intravenous injection; once weekly for 4 weeks, single dose) significantly prolongs the survival of NXG mice bearing disseminated Hodgkin lymphoma, with treated mice surviving for more than 80 days^[1].
Nampt-IN-22 (conjugated to anti-CD30 antibody, DAR10) (administered intravenously once weekly for 4 weeks) achieves significant tumor inhibition in CB-17 SCID mice subcutaneously inoculated with Hodgkin lymphoma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3087291-80-0
Molecular Weight 435.52
Formel C₂₃H₂₉N₇O₂
SMILES

N#C/N=C(NC1=CC=CN=C1)\NCCCCC2(O)CCN(C(C3=CC=CC(N)=C3)=O)CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ruedas P, et al. Physicochemical and Metabolic Optimization of NAMPT Inhibitors Enables Effective Antibody–Drug Conjugates for Liquid and Solid Tumors[J]. ACS Bio & Med Chem Au, 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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