1382 Results for "

tnf-

" in MedChemExpress (MCE) Product Catalog:
Products (1382)

1382 Results for "tnf-" in MCE Product Catalog:

500
Resatorvid
Resatorvid
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500 Publications Verification
Art. -Nr.: HY-11109
CAS. Nr.: 243984-11-4
Reinheit:  98.92%
Synonyms: TAK-242; CLI-095
Target:  

Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy

Forschungsgebiete:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .
454
BAY 11-7082
BAY 11-7082
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454 Cited Publications
Art. -Nr.: HY-13453
CAS. Nr.: 19542-67-7
Reinheit:  99.98%
Synonyms: BAY 11-7821
Target:  

IKK Deubiquitinase Autophagy Apoptosis NF-κB

Forschungsgebiete:  

Inflammation/Immunology Cancer

BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .
111
Resiquimod
Resiquimod
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111 Cited Publications
Art. -Nr.: HY-13740
CAS. Nr.: 144875-48-9
Reinheit:  99.87%
Synonyms: R848; S28463
Target:  

Toll-like Receptor (TLR) HCV

Forschungsgebiete:  

Inflammation/Immunology Cancer

Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α.
66
Shikonin
Shikonin
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66 Cited Publications
Art. -Nr.: HY-N0822
CAS. Nr.: 517-89-5
Synonyms: C.I. 75535; Isoarnebin 4
Category:  

Quinones Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Boraginaceae Naphthalene Quinones Cancer

Target:  

Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2

Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .
61
TNF-alpha/TNFSF2 Protein, Human
TNF-alpha/TNFSF2 Protein, Human
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61 Cited Publications
Art. -Nr.: HY-P7058
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHutnf-α/tnfSF2; tnf-alpha; Cachectin; DIF; tnfA; Differentiation-inducing factor; tnfα
Species:  
Human
Source:  
E. coli
61
GSK-J4 hydrochloride
GSK-J4 hydrochloride
0 Images
61 Cited Publications
Art. -Nr.: HY-15648F
CAS. Nr.: 1797983-09-5
Reinheit:  99.01%
Target:  

Histone Demethylase

Forschungsgebiete:  

Cancer

GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .
61
GSK-J4
GSK-J4
0 Images
61 Cited Publications
Art. -Nr.: HY-15648B
CAS. Nr.: 1373423-53-0
Reinheit:  99.64%
Target:  

Histone Demethylase Apoptosis

Forschungsgebiete:  

Cancer

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .
51
Doramapimod hydrochloride
Doramapimod hydrochloride
0 Images
51 Cited Publications
Art. -Nr.: HY-10320A
CAS. Nr.: 1283526-53-3
Synonyms: BIRB 796 hydrochloride
Target:  

Autophagy Raf p38 MAPK

Forschungsgebiete:  

Inflammation/Immunology

Doramapimod hydrochloride (BIRB 796 hydrochloride) is an anti-inflammatory compound with biological activity through inhibition of p38 MAPK. Doramapimod hydrochloride can significantly inhibit the activities of TNF-α and IL-1β induced by LPS, LTA and PGN. Doramapimod hydrochloride showed a stronger inhibitory effect on inflammation induced by all three bacterial toxins, which was more significant compared with the effects of other compounds. Doramapimod hydrochloride can be used in the research of autoimmune diseases .
49
QNZ
QNZ
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49 Cited Publications
Art. -Nr.: HY-13812
CAS. Nr.: 545380-34-5
Reinheit:  99.50%
Synonyms: EVP4593
Target:  

NF-κB TNF Receptor

Forschungsgebiete:  

Neurological Disease Inflammation/Immunology

QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.
44
Birinapant
Birinapant
0 Images
44 Cited Publications
Art. -Nr.: HY-16591
CAS. Nr.: 1260251-31-7
Synonyms: TL32711
Target:  

IAP Apoptosis HIV

Forschungsgebiete:  

Cancer

Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.
30
TNF-alpha/TNFSF2 Protein, Mouse (156a.a)
TNF-alpha/TNFSF2 Protein, Mouse (156a.a)
0 Images
30 Cited Publications
Art. -Nr.: HY-P7090
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rMutnf-α/tnfSF2; tnf-alpha; Cachectin; DIF; tnfA; Differentiation-inducing factor
Species:  
Mouse
Source:  
E. coli
30
Takinib
Takinib
0 Images
30 Cited Publications
Art. -Nr.: HY-103490
CAS. Nr.: 1111556-37-6
Reinheit:  99.41%
Synonyms: EDHS-206
Target:  

MAP3K Apoptosis

Forschungsgebiete:  

Infection Inflammation/Immunology Cancer

Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 μM) .
29
R-7050
R-7050
0 Images
29 Cited Publications
Art. -Nr.: HY-110203
CAS. Nr.: 303997-35-5
Reinheit:  99.96%
Synonyms: tnf-α Antagonist III
Target:  

TNF Receptor

Forschungsgebiete:  

Cancer

R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
27
Infliximab
Infliximab
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27 Cited Publications
Art. -Nr.: HY-P9970
CAS. Nr.: 170277-31-3
Synonyms: Avakine; CT-P13; SB2; TA-650

Target:  

TNF Receptor

Forschungsgebiete:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research .
The component ratio of this product is Active ingredient : Excipients = 9 : 47.
26
IMD-0354
IMD-0354
0 Images
26 Cited Publications
Art. -Nr.: HY-10172
CAS. Nr.: 978-62-1
Reinheit:  99.26%
Synonyms: IKK2 Inhibitor V
Target:  

IKK

Forschungsgebiete:  

Cancer

IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM .
25
Piceatannol
Piceatannol
0 Images
25 Cited Publications
Art. -Nr.: HY-13518
CAS. Nr.: 10083-24-6
Reinheit:  98.97%
Synonyms: Astringenin; trans-Piceatannol
Category:  

Microorganisms Rheum palmatum L. Stilbenes Polygonaceae Plants Disease Research Fields Cancer

Target:  

Syk Autophagy Apoptosis Endogenous Metabolite

Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells .
24
Beta-Sitosterol (purity>80%)
Beta-Sitosterol (purity>80%)
0 Images
24 Cited Publications
Art. -Nr.: HY-N0171
CAS. Nr.: 83-46-5
Category:  

Cardiovascular Disease other families Leguminosae Plants Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Steroids

Target:  

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
22
Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%)
0 Images
22 Cited Publications
Art. -Nr.: HY-N0171A
CAS. Nr.: 83-46-5
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
Category:  

Cardiovascular Disease Leguminosae Glycine max (L.) merr Plants Disease Research Fields Inflammation/Immunology Steroids

Target:  

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
17
c-di-AMP disodium
c-di-AMP disodium
0 Images
17 Cited Publications
Art. -Nr.: HY-12326A
CAS. Nr.: 2734909-87-4
Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
17
c-di-AMP diammonium
c-di-AMP diammonium
0 Images
17 Cited Publications
Art. -Nr.: HY-12326B
Reinheit:  99.36%
Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

STING Bacterial Endogenous Metabolite

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
Assay Types