978-62-1
978-62-1
Chemical Structure
IMD-0354
Synonym(s): IKK2 Inhibitor V
- CAS No.: 978-62-1
- Formula:C15H8ClF6NO2
- Molecular Weight:383.67
IUPAC Name: N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
InChIKey: CHILCFMQWMQVAL-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C2=CC(Cl)=CC=C2O
Biological Activity: IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity[1]. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM[2].
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IMD-0354 | 99.26% | IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM. | ||||||||||||||||||||
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IMD-0354 (Standard) | ≥98% | IMD-0354 (Standard) is the analytical standard of IMD-0354. This product is intended for research and analytical applications. IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM. | ||||||||||||||||||||
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References
- [1]. Tanaka A, et al. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood. 2005 Mar 15;105(6):2324-31. [Content Brief]
- [2]. Li YR, et al. Study of the inhibitory effects on TNF-α-induced NF-κB activation of IMD0354 analogs. Chem Biol Drug Des. 2017 Dec;90(6):1307-1311. [Content Brief]
