2. Anti-infection
  3. Fungal
  4. 3',5,5'-Trichlorosalicylanilide

3',5,5'-Trichlorosalicylanilide (TCSA) acts as an inhibitor of fungal morphogenesis, preventing biofilm formation and hindering host cell invasion.

For research use only. We do not sell to patients.

3',5,5'-Trichlorosalicylanilide

3',5,5'-Trichlorosalicylanilide Chemical Structure

CAS No. : 106480-60-8

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3',5,5'-Trichlorosalicylanilide Related Antibodies

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Description

3',5,5'-Trichlorosalicylanilide (TCSA) acts as an inhibitor of fungal morphogenesis, preventing biofilm formation and hindering host cell invasion.

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
0.7 μM
Compound: 18
Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs
Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs
[PMID: 26272032]
J774.A1 CC50
38.75 μM
Compound: 27
Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability by MTT assay
[PMID: 36565533]
Macrophage IC50
3.1 μM
Compound: 76
Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue
Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue
[PMID: 23211970]
Platelet IC50
>10 μM
Compound: 39
Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of TRAP6-induced platelet aggregation pre-incubated for 30 mins before TRAP6 stimulation by aggregometry
Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of TRAP6-induced platelet aggregation pre-incubated for 30 mins before TRAP6 stimulation by aggregometry
[PMID: 32345019]
Platelet IC50
>20 μM
Compound: 39
Antagonist activity P2X1 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation pre-incubated for 30 mins before ADP stimulation by aggregometry
Antagonist activity P2X1 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation pre-incubated for 30 mins before ADP stimulation by aggregometry
[PMID: 32345019]
Platelet IC50
3.03 μM
Compound: 39
Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of collagen-induced platelet aggregation pre-incubated for 30 mins before collagen stimulation by aggregometry
Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of collagen-induced platelet aggregation pre-incubated for 30 mins before collagen stimulation by aggregometry
[PMID: 32345019]
Vero CC50
6.49 μM
Compound: 27
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay
[PMID: 36565533]
Molecular Weight

316.57

Formula

C13H8Cl3NO2
CAS No.
SMILES

O=C(C1=CC(Cl)=CC=C1O)NC2=CC(Cl)=CC(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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3',5,5'-Trichlorosalicylanilide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3',5,5'-Trichlorosalicylanilide106480-60-8TCSAFungalInhibitorinhibitorinhibit

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