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Cat. No.: HY-W706466

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3',5,5'-Trichlorosalicylanilide

(Synonyms: TCSA)

3',5,5'-Trichlorosalicylanilide (TCSA) acts as an inhibitor of fungal morphogenesis, preventing biofilm formation and hindering host cell invasion.

For research use only. We do not sell to patients.

CAS No.: 106480-60-8
Formula: C₁₃H₈Cl₃NO₂
Molecular Weight:316.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

3',5,5'-Trichlorosalicylanilide Chemical Structure

CAS No.: 106480-60-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
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Biological Activity

Description

3',5,5'-Trichlorosalicylanilide (TCSA) acts as an inhibitor of fungal morphogenesis, preventing biofilm formation and hindering host cell invasion.

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.7 μM Compound: 18	Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs Inhibition of Wnt/beta-catenin in HEK293 cells assessed as inhibition of Wnt3A-stimulated TOPFlash activity after 8 hrs	[PMID: 26272032]
J774.A1	CC₅₀	38.75 μM Compound: 27	Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability by MTT assay	[PMID: 36565533]
Macrophage	IC₅₀	3.1 μM Compound: 76	Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue Cytotoxicity against mouse macrophage cell line J774.1 (ATCC TIB-67) for 3 days by Alamar Blue	[PMID: 23211970]
Platelet	IC₅₀	>10 μM Compound: 39	Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of TRAP6-induced platelet aggregation pre-incubated for 30 mins before TRAP6 stimulation by aggregometry Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of TRAP6-induced platelet aggregation pre-incubated for 30 mins before TRAP6 stimulation by aggregometry	[PMID: 32345019]
Platelet	IC₅₀	>20 μM Compound: 39	Antagonist activity P2X1 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation pre-incubated for 30 mins before ADP stimulation by aggregometry Antagonist activity P2X1 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation pre-incubated for 30 mins before ADP stimulation by aggregometry	[PMID: 32345019]
Platelet	IC₅₀	3.03 μM Compound: 39	Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of collagen-induced platelet aggregation pre-incubated for 30 mins before collagen stimulation by aggregometry Antagonist activity P2X1 receptor in Apyrase pre-treated human platelets assessed as inhibition of collagen-induced platelet aggregation pre-incubated for 30 mins before collagen stimulation by aggregometry	[PMID: 32345019]
Vero	CC₅₀	6.49 μM Compound: 27	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay	[PMID: 36565533]

Chemical Information

CAS No. 106480-60-8
Molecular Weight 316.57
Formula C₁₃H₈Cl₃NO₂
SMILES

O=C(C1=CC(Cl)=CC=C1O)NC2=CC(Cl)=CC(Cl)=C2
Synonyms

TCSA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.