Art. -Nr.: HY-15756

PTP1B-IN-4

1 Cited Publications

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PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC₅₀ of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes.

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Reinheit: 99.55%
CAS. Nr.: 765317-72-4
Formel: C₂₆H₁₉Br₂N₃O₇S₃
Molecular Weight:741.45

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

PTP1B-IN-4 Chemical Structure

CAS. Nr.: 765317-72-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC₅₀ of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes^[1]^[2].

IC₅₀ & Target

IC50: 8 μM (PTP1B)^[1]

In Vitro

PTP1B-IN-4 (250 μM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR^[1].
PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

CHO cells
Concentration:

250 µM
Incubation Time:

1 hour
Result:

Stimulated insulin receptor phosphorylation.

Chemical Information

CAS. Nr. 765317-72-4
Appearance Solid
Molecular Weight 741.45
Formel C₂₆H₁₉Br₂N₃O₇S₃
Color White to off-white
SMILES

O=S(C1=CC=C2C(C(C3=CC(Br)=C(O)C(Br)=C3)=O)=C(CC)OC2=C1)(NC4=CC=C(S(=O)(NC5=NC=CS5)=O)C=C4)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Cell Rep

Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrix. [Abstract]

2025 Dec 6;44(12):116649. PMID: 41359424

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (134.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3487 mL

6.7435 mL

13.4871 mL

5 mM

0.2697 mL

1.3487 mL

2.6974 mL

10 mM

0.1349 mL

0.6744 mL

1.3487 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (2.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wiesmann, C., et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology, 2004. 11(8), 730–737.

[2]. Jin, T., et al. Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B. Scientific Reports, 2016. 6(1).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3487 mL	6.7435 mL	13.4871 mL	33.7177 mL
	5 mM	0.2697 mL	1.3487 mL	2.6974 mL	6.7435 mL
	10 mM	0.1349 mL	0.6744 mL	1.3487 mL	3.3718 mL
	15 mM	0.0899 mL	0.4496 mL	0.8991 mL	2.2478 mL
	20 mM	0.0674 mL	0.3372 mL	0.6744 mL	1.6859 mL
	25 mM	0.0539 mL	0.2697 mL	0.5395 mL	1.3487 mL
	30 mM	0.0450 mL	0.2248 mL	0.4496 mL	1.1239 mL
	40 mM	0.0337 mL	0.1686 mL	0.3372 mL	0.8429 mL
	50 mM	0.0270 mL	0.1349 mL	0.2697 mL	0.6744 mL
	60 mM	0.0225 mL	0.1124 mL	0.2248 mL	0.5620 mL
	80 mM	0.0169 mL	0.0843 mL	0.1686 mL	0.4215 mL
	100 mM	0.0135 mL	0.0674 mL	0.1349 mL	0.3372 mL

Keywords

PTP1B-IN-4

1 Cited Publications

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PTP1B-IN-4

Bioactive Compound Library Max

Bioactive Compound Library

Metabolism/Protease Compound Library

Anti-diabetic Compound Library

Phosphatase Inhibitor Library

Anti-Obesity Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) PTP1B-IN-4

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PTP1B-IN-4

Bioactive Compound Library Max

Bioactive Compound Library

Metabolism/Protease Compound Library

Anti-diabetic Compound Library

Phosphatase Inhibitor Library

Anti-Obesity Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) PTP1B-IN-4

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PTP1B-IN-4 Related Classifications

HY-15756 Related Classifications