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Art. -Nr.: HY-116233

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ROCK-IN-13

ROCK-IN-13 is a ROCK2 inhibitor with an IC₅₀ of 8 nM against human ROCK2. ROCK-IN-13 has the potential for use in the research of diseases such as multiple sclerosis, glaucoma, and cardiovascular diseases.

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CAS. Nr.: 1219727-16-8
Formel: C₂₀H₂₂N₄O
Molecular Weight:334.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ROCK-IN-13 Chemical Structure

CAS. Nr.: 1219727-16-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

ROCK2

8 nM (IC₅₀)

Alle ROCK Isoform-spezifische Produkte anzeigen :

In Vitro

ROCK-IN-13 (Compound D3) (4 h) potently inhibits recombinant human ROCK2, with an IC₅₀ value of 8 nM^[1].
ROCK-IN-13 (70 min) weakly inhibits recombinant human PKA, with an experimental IC₅₀ of 3381 nM, and shows 422-fold higher selectivity for ROCK2 than for PKA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1219727-16-8
Molecular Weight 334.41
Formel C₂₀H₂₂N₄O
SMILES

O=C(N(C(C)C)CC1=CC=CC=C1)NC2=CC=C(C=C2)C3=CNN=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mei D, Yin Y, Wu F, et al.. Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations. Bioorganic & medicinal chemistry. 2015 May 15;23(10):2505-17. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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ROCK-IN-13

Alle ROCK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

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ROCK-IN-13 Related Classifications

HY-116233 Related Classifications