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Art. -Nr.: HY-183145

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RORγ-IN-4

RORγ-IN-4 is a RORγ inhibitor with an EC₅₀ of 0.014 μM. RORγ-IN-4 can be used for the research of inflammation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1608139-41-8
Formel: C₂₆H₃₀ClN₃O₅
Molecular Weight:499.99

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

RORγ-IN-4 Chemical Structure

CAS. Nr.: 1608139-41-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

RORγ-IN-4 is a RORγ inhibitor with an EC₅₀ of 0.014 μM. RORγ-IN-4 can be used for the research of inflammation^[1].

IC₅₀ & Target^[1]

RORγ

0.014 μM (EC₅₀)

Alle ROR Isoform-spezifische Produkte anzeigen :

In Vitro

RORγ-IN-4 (non-salt form of Compound 12) potently inhibits RORγ in a luciferase reporter assay with an EC₅₀ of 0.014 μM, exhibits favorable metabolic stability in human liver microsomes, and demonstrates high apparent permeability in Caco2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1608139-41-8
Molecular Weight 499.99
Formel C₂₆H₃₀ClN₃O₅
SMILES

ClC(C=C(C=C1)C)=C1NC(C[C@@H](C2=NOC(C3=NOC(CC(C)C)=C3)=C2C4CC4)CCC(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kotoku M, et al. Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold. J Med Chem. 2019;62(5):2837-2842. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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RORγ-IN-4

Alle ROR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

RORγ-IN-4 Related Classifications

HY-183145 Related Classifications