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Art. -Nr.: HY-151269

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SARS-CoV-2-IN-26

SARS-CoV-2-IN-23 is a two-armed diphosphate ester and medium length molecular tweezers. SARS-CoV-2-IN-23 exhibits antiviral activity with IC₅₀s of 8.2 μM and 2.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-23 induces liposomal membrane disruption with an EC₅₀ value of 4.4 μM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₅₂H₅₂O₈P₂
Molecular Weight:866.91

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SARS-CoV-2-IN-26 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 4.4 μM (viral liposome, SARS-CoV-2)^[1]

In Vitro

SARS-CoV-2-IN-23 (CP002) inhibits SARS-CoV-2 (IC₅₀=2.6 μM) with a low cytotoxicity (Caco2 cells, CC₅₀=97 μM)^[1].
SARS-CoV-2-IN-23 (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC₅₀ value of 8.2 μM^[1].
SARS-CoV-2-IN-23 suppresses varies enveloped viruses activity with IC₅₀s of 38.4 μM (influenza A virus, IAV), 2.8 μM (measles virus, MeV), 1.1 μM (herpes simplex viruses, HSV-1), and human immunodeficiency virus type 1 (HIV-1), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration:

0, 0.23, 0.93, 3.75, 15 μM
Incubation Time:

2 hours; determined infection rates on day 2
Result:

Inhibited SARS-CoV-2 infection activity to Caco2 cells.

Chemical Information

Molecular Weight 866.91
Formel C₅₂H₅₂O₈P₂
SMILES

CC(CCOP(OC1=C2C(C3C4=C(C2C3)C=C5C(C6C7=C(C5C6)C=CC=C7)=C4)=C(C8=C1C9C%10=CC(C%11CC%12C%13=C%11C=CC=C%13)=C%12C=C%10C8C9)OP(OCCC(C)C)(O)=O)(O)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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