Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
163 Results for "
Pyrazole
" in MedChemExpress (MCE) Product Catalog:
Products (163)
163 Results for "Pyrazole" in MCE Product Catalog:
19
19 Publications Verification
Synonyms: PPT
Target:
Forschungsgebiete:
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .
8
8 Cited Publications
Synonyms: PHA-739358
Target:
Forschungsgebiete:
Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively.
3
3 Cited Publications
Art. -Nr.: HY-19408
CAS. Nr.: 1315323-00-2
Target:
Forschungsgebiete:
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca 2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca 2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .
3
3 Cited Publications
Target:
Forschungsgebiete:
DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia .
2
2 Cited Publications
Target:
Forschungsgebiete:
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) .
2
2 Cited Publications
Target:
Forschungsgebiete:
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
2
2 Cited Publications
Target:
Forschungsgebiete:
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion .
1
1 Cited Publications
Art. -Nr.: HY-41514
CAS. Nr.: 1627924-19-9
Target:
Forschungsgebiete:
3-Iodo-1-tetrahydropyran-2-yl-pyrazole-4-carbaldehyde is a drug intermediate for synthesis of various active compounds.
1
1 Cited Publications
Synonyms: Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate
Target:
1
Target:
Forschungsgebiete:
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity .
1
Target:
Forschungsgebiete:
Betazole hydrochloride (Ametazole hydrochloride), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity .
1
1 Cited Publications
Target:
Forschungsgebiete:
BI-1935, a chemical probe, is a potent soluble epoxide hydrolase (sEH) inhibitor. BI-1935 can be used for the research of cardiovascular disease .
Art. -Nr.: HY-W017032
CAS. Nr.: 4023-02-3
Art. -Nr.: HY-W002736
CAS. Nr.: 152120-54-2
Art. -Nr.: HY-I0308
CAS. Nr.: 761446-44-0
Art. -Nr.: HY-W001242
CAS. Nr.: 903550-26-5
Art. -Nr.: HY-I0314
CAS. Nr.: 269410-08-4
Target:
Forschungsgebiete:
Nifenazone is a pyrazole agent which can be used in the in the treatment of a variety of rheumatic disorders.
Art. -Nr.: HY-69052
CAS. Nr.: 25016-11-9
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
