1134613-19-6
Chemical Structure
CW 008
- CAS No.: 1134613-19-6
- Formula:C21H14F2N6O2
- Molecular Weight:420.37
IUPAC Name: 4-fluoro-N-(5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)benzamide
InChIKey: KCIMKTNQCUDTFI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)F)NC2=NNC3=C2C=C(F)C(C4=C5C=C(OC)C=CN5N=C4)=N3
Biological Activity: CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CW 008 | 98.52% | CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion. | ||||||||||||||||||||
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References
- [1]. Nooshin AMINI, et al. Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons. Patent, WO2023075913A1.
- [2]. Patrick Soon-Shiong. Patient treatment via teratogenic pharmaceutical compounds. Patent, WO2016176675A2.
- [3]. Kim JM, et al. An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J Cell Physiol. 2013 Mar;228(3):617-26. [Content Brief]
