903550-26-5
903550-26-5
Chemical Structure
1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester
- CAS No.: 903550-26-5
- Formula:C14H23BN2O3
- Molecular Weight:278.16
IUPAC Name: 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
InChIKey: ZZRFDLHBMBHJTI-UHFFFAOYSA-N
SMILES: CC(C(C)(O1)C)(OB1C2=CC=NN2C3CCCCO3)C
Biological Activity: 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester is a pharmaceutical intermediate used in the synthesis of naphthyl FXIa/PKa inhibitors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester | 98.0% | 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester is a pharmaceutical intermediate used in the synthesis of naphthyl FXIa/PKa inhibitors. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.55
HY-W0081473-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine -
Similarity Score 0.55
HY-W2439932-(4-(5,5-Dimethyl-1,3-dioxan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane -
Similarity Score 0.55
HY-W1184591-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine -
Similarity Score 0.54
HY-W0123862-Fluoropyridine-5-boronic acid pinacol ester -
Similarity Score 0.54
![N,N-Dimethyl-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetamide Chemical Structure](//file.medchemexpress.com/product_pic/hy-43045.gif)
HY-43045N,N-Dimethyl-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetamide -
Similarity Score 0.54
HY-W0032331-Boc-pyrazole-4-boronic acid pinacol ester -
Similarity Score 0.53
HY-W0030493-Carboxyphenylboronic acid pinacol ester -
Similarity Score 0.53
HY-W0008874-Carboxyphenylboronic acid pinacol ester -
Similarity Score 0.53
HY-W0028794-Hydroxyphenylboronic acid pinacol ester -
Explore the MedChemAI to find more analogs
![N,N-Dimethyl-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetamide Chemical Structure](http://file.medchemexpress.com/product_pic/hy-43045.gif)
References
- [1]. Zhan M, et al. Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors. J Med Chem. 2017;60(9):4023-4035. [Content Brief]
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[2]. Zhang Y, et al. Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments. Medicinal Chemistry Research. 2024 Jun;33(6):1003-23.
