PDGFA - platelet derived growth factor subunit A Gene

Also Known as PDGF1; PDGF-A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5154

About PDGFA

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:497,258-520,700 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 8.8), placenta (RPKM 8.7) and 24 other tissues.

Summary

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF Receptor Tyrosine Kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

PDGFA Products (6)

mRNA	Protein	Name
NM_001395363.1	NP_001382292.1	platelet-derived growth factor subunit A isoform 3
NM_001395364.1	NP_001382293.1	platelet-derived growth factor subunit A isoform 4
NM_001395365.1	NP_001382294.1	platelet-derived growth factor subunit A isoform 5
NM_001395366.1	NP_001382295.1	platelet-derived growth factor subunit A isoform 2 preproprotein
NM_002607.6	NP_002598.4	platelet-derived growth factor subunit A isoform 1 preproprotein
NM_033023.5	NP_148983.1	platelet-derived growth factor subunit A isoform 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IDA IDA: Inferred from direct assay	8900172	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	12070119	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20534510	GOA
enables platelet-derived growth factor binding	IPI IPI: Inferred from physical interaction	7073684	GOA
enables platelet-derived growth factor receptor binding	IDA IDA: Inferred from direct assay	2439522	GOA
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	2536956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7679113	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	7073684	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	2836953	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative chemotaxis	IDA IDA: Inferred from direct assay	9409235	GOA
involved in negative regulation of phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	2538439	GOA
involved in negative regulation of platelet activation	IDA IDA: Inferred from direct assay	2538439	GOA
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11788434	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11788434	GOA
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16462734	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IDA IDA: Inferred from direct assay	19019919	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	12070119	GOA
NOT involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	11788434	GOA
NOT involved in regulation of glomerular mesangial cell proliferation	IDA IDA: Inferred from direct assay	11788434	GOA
involved in regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	9409235	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	2538439	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	291037	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	3754619	GOA
part of platelet-derived growth factor complex	IPI IPI: Inferred from physical interaction	7679113	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFA Protein Structure

PDGF_N

PDGF

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor subunit A	PDGF A-chain

PDGFA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDGFA	P04085	PDGFRA	Homo sapiens	P16234	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDGFA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70598	PDGF-AA Protein, Human	P04085-1 (S87-T211)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70825	PDGF-AA Protein, Human (His)	P04085-1 (S87-T211)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74643	PDGF-AA Protein, Human (P.pastoris, His)	P04085-1 (S87-T211)	≥ 90%, as determined by reducing SDS-PAGE.

PDGFA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83935	PDGFA Antibody (YA3632)	ICC/IF, FC, ELISA	Human, Mouse
HY-P83935A	PDGFA Antibody (YA3632)(PBS only)	ICC/IF, FC, ELISA	Human, Mouse
HY-P83936	PDGFA Antibody (YA3633)	IHC-P, FC, ELISA	Human, Mouse
HY-P83936A	PDGFA Antibody (YA3633)(PBS only)	IHC-P, FC, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Denys-Drash Syndrome	Drash Syndrome DDS Nephropathy, Wilms Tumor, And Genital Anomalies Wilms Tumor And Pseudohermaphroditism Wilms Tumor And Pseudo- Or True Hermaphroditism Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor Wilms Tumor-Dsd Syndrome Wilms Tumor-Disorder Of Sex Development Syndrome
Ureteral Obstruction
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Glioma
Diffuse Mesangial Sclerosis	Familial Mesangial Sclerosis Mesangial Sclerosis, Diffuse Dms Diffuse Isolated Mesangial Sclerosis Isolated Diffuse Mesangial Sclerosis Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis
Familiar Ovarian Carcinoma
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Ureter Small Cell Carcinoma	Ureteral Small Cell Carcinoma
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Bronchiectasis 2
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Asbestos-Related Lung Carcinoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0889	Glycylglycine		99.90%	Unkown
HY-D0889R	Glycylglycine (Standard)		99.91%	Unkown
HY-RS10250	PDGFA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174553	Human PDGFA mRNA		/	Unkown
HY-RS17304	Pdgfa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23759	Pdgfa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W040074	Glycylglycine hydrochloride hydrate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDGFA	VGNC	VGNC:75926
Mus musculus	PDGFA	MGD	MGI:97527
Rattus norvegicus	PDGFA	RGD	RGD:3282
Canis familiaris	PDGFA	VGNC	VGNC:44368
Felis catus	PDGFA	VGNC	VGNC:68768
Bos taurus	PDGFA	VGNC	VGNC:32689
Others	PDGFA	NCBI