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Cat. No.: HY-149846

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SIQ17

SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC₅₀ of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC₅₀ of ∼20 nM). SIQ17 can be used for cancer research

For research use only. We do not sell to patients.

CAS No.: 2151881-74-0
Formula: C₃₂H₂₇NO₂S
Molecular Weight:489.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SIQ17 Chemical Structure

CAS No.: 2151881-74-0

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All EGFR Isoforms :

In Vitro

SIQ17 (10 μM, 72 hours) has a stronger inhibits on cell viability of A431 cells compare to A549 cells^[1].
SIQ17 (0-100 μM, 24 hours) has thecytotoxic effects, with IC₅₀s of 32.98 μM and 19.17μM for A549 cells and A431 cells respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A549, A431
Concentration:

10 μM
Incubation Time:

72 hours
Result:

Had a stronger inhibits on cell viability of A431 cells compare to A549 cells

Cell Cytotoxicity Assay^[1]

Cell Line:

A549, A431, Vero cell lines
Concentration:

0-100 μM
Incubation Time:

24 hours
Result:

Had thecytotoxic effects, with IC₅₀s of 32.98μM and 19.17μM for A549 cells and A431 cells respectively.

Chemical Information

CAS No. 2151881-74-0
Molecular Weight 489.63
Formula C₃₂H₂₇NO₂S
SMILES

O=S(C(C1=C2C=CC=C1)=C3C2=C(C4=CC=C(C)C=C4C)N(C)C5=C3C=CC=C5)(C6=CC=C(C)C=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hengphasatporn K,et.al. Sulfonylated Indeno[1,2-c]quinoline Derivatives as Potent EGFR Tyrosine Kinase Inhibitors. ACS Omega. 2023 May 23;8(22):19645-19655. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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SIQ17

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SIQ17 Related Classifications

HY-149846 Related Classifications