Antibacterial agent 89
Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription.
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- CAS No.: 2589639-87-0
- Formule: C21H10Cl2F3NO5S
- Masse moléculaire:516.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
18.4 nM
Compound: 8e
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Cytotoxicity against human A549 cells after 48 to 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 to 72 hrs by MTT assay
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[PMID: 32920341] |
| HepG2 | CC50 |
387 μM
Compound: 8e
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Cytotoxicity against human HepG2 cells after 48 to 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 to 72 hrs by MTT assay
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[PMID: 32920341] |
Antibacterial agent 89 (compound 8 e) shows antimicrobial activity for SPNE (Streptococcus pneumoniae (S. pneumoniae)) ATCC 49619, Streptococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213 with MIC of 2, 4, 4 µg/mL, respectively[1].
Antibacterial agent 89 (48 h) shows anti-clostridial activity against clinically important Gram-positive pathogens with MIC of 0-8 µg/mL[1].
Antibacterial agent 89 (48 h) inhibits the release of cytotoxins Toxin A (TcdA) and Toxin B (TcdB) in a dose-dependent manner in C. difficile ATCC 9689, ribotype 002, ribotype 027[1].
Antibacterial agent 89 inhibits the β’CH-σ interaction with an IC50 of 2.12 µM[1].
Antibacterial agent 89 (1, 2, 4 µg/mL; B. subtilis) alters the localization of bacterial transcription complexes[1].
Antibacterial agent 89 (0.5, 0.25 µg/mL) reduces the expression of DNA, RNA, protein levels in S. aureus ATCC 29213 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. aureus ATCC 29213 cells
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Concentration:0.5, 0.25 µg/mL
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Incubation Time:
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Result:Reduced the total levels of protein observed in S. aureus ATCC 29213 cells.
Chemical Information
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CAS No. 2589639-87-0
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Masse moléculaire 516.27
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Formule C21H10Cl2F3NO5S
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SMILES
O=C(C1=CC=C(C=C1C(C2=CC([N+]([O-])=O)=C(C=C2)SC3=CC(Cl)=C(C=C3)Cl)=O)C(F)(F)F)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 89 Related Classifications
HY-146722 Related Classifications
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